ID A0A409YHG3_9AGAR Unreviewed; 581 AA.
AC A0A409YHG3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=FAD-binding domain-containing protein {ECO:0000259|Pfam:PF01494};
GN ORFNames=CVT26_011382 {ECO:0000313|EMBL:PPR02414.1};
OS Gymnopilus dilepis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Hymenogastraceae; Gymnopilus.
OX NCBI_TaxID=231916 {ECO:0000313|EMBL:PPR02414.1, ECO:0000313|Proteomes:UP000284706};
RN [1] {ECO:0000313|EMBL:PPR02414.1, ECO:0000313|Proteomes:UP000284706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRW20 {ECO:0000313|EMBL:PPR02414.1,
RC ECO:0000313|Proteomes:UP000284706};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride + FADH2 + melleolide F + O2 = 6'-chloromelleolide F +
CC FAD + H(+) + 2 H2O; Xref=Rhea:RHEA:67160, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:167712,
CC ChEBI:CHEBI:167713; Evidence={ECO:0000256|ARBA:ARBA00036433};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67161;
CC Evidence={ECO:0000256|ARBA:ARBA00036433};
CC -!- SIMILARITY: Belongs to the flavin-dependent halogenase family.
CC {ECO:0000256|ARBA:ARBA00005706}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPR02414.1}.
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DR EMBL; NHYE01000846; PPR02414.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409YHG3; -.
DR STRING; 231916.A0A409YHG3; -.
DR InParanoid; A0A409YHG3; -.
DR OrthoDB; 1599601at2759; -.
DR Proteomes; UP000284706; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0140907; F:flavin-dependent halogenase activity; IEA:UniProt.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR PANTHER; PTHR43747:SF1; FAD-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000284706}.
FT DOMAIN 10..130
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
SQ SEQUENCE 581 AA; 63533 MW; 8C84DBD462D17E27 CRC64;
MSSSIPPRHT QVLIVGGGPA GSYAAAALAR EGVQVTLLEA YHIGESLIPS VRHYLRFIGA
EEKMVKHGFI PKPGSAMKFN QFKREGYTDF VALGNNNSSW NVIRSEFDQM LLNHARSLGV
SVYEQTKVEK ISFSSADPNR PISVSWVHTP PPCPPSPPAS PTDSKFSFFP PNFSPWSHEP
SIVHGETKFD YLIDATGRAG IMSTQYLKNR RFNASLKNMA VWGYWQNAGK YGLGSARYGS
PWFEALTDET GWAWFIPLHD GTTSVGVVMN EKAFKEKGHN PPPSPFSPTA TPFPVNSSIA
SRYLGSLGLA PGIVDLISAS GVLKVGSIKS ANDFSYSAPS YAGPGYRIVG DAGAFIDPFF
SSGVHLAMTS ALSAAATVCA SIRGHCSESV ASDFHTRRIA TSYTRFQVVV LSAYKQIRSQ
SDNILSDIDE DNYDRAFSFL RPVIQGASDM GARLSETELQ KSLDFCVNLF NPTTPEQHER
LARRSDIAKE LLDVSRPVVD PSVLEASCPH NHRHDTTRSR SDSSLKCEEE VETKMILNKI
NARRVVHPEY AINNLELEPL AGYAVKLERG ALGLKKAVVG P
//
