ID A0A409YVN8_9AGAR Unreviewed; 2095 AA.
AC A0A409YVN8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=CVT24_010921 {ECO:0000313|EMBL:PPR07084.1};
OS Panaeolus cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Galeropsidaceae; Panaeolus.
OX NCBI_TaxID=181874 {ECO:0000313|EMBL:PPR07084.1, ECO:0000313|Proteomes:UP000284842};
RN [1] {ECO:0000313|EMBL:PPR07084.1, ECO:0000313|Proteomes:UP000284842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2629 {ECO:0000313|EMBL:PPR07084.1,
RC ECO:0000313|Proteomes:UP000284842};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPR07084.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NHTK01000526; PPR07084.1; -; Genomic_DNA.
DR STRING; 181874.A0A409YVN8; -.
DR InParanoid; A0A409YVN8; -.
DR OrthoDB; 1614913at2759; -.
DR Proteomes; UP000284842; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR046700; DUF6570.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF20209; DUF6570; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000284842}.
FT DOMAIN 119..250
FT /note="DUF6570"
FT /evidence="ECO:0000259|Pfam:PF20209"
FT DOMAIN 379..597
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
SQ SEQUENCE 2095 AA; 236443 MW; 1EFD5D6C02B9F112 CRC64;
MSEGSSSFVW DSFRAPDKQE FPPPPCTPKR IAAAMRDYCR DIGPSVIEES GCAVCGQLTR
RSNMLLLNEL DIKLSPLTQV NCAKHERLSS NDPDCDISGP VYDTKLSSVC PECCTALKKG
RRPRLALANN LWLGEVPDQL KGLTWAEQAV IARVRHNRCV VRISSGHSKM IGNVIAFEHP
TMKVYDILPP SVDELNDVLA VIFTGMEPPT PEDLKRTPVL VRRQVILDAL LWLKLNHKDY
KYITIDHDTL ATYPEEGIPV KVIHKAMDVS EGNVLATAKS VFDNDDEIGT ETGPCPFSVH
GLTADRFASM TSSQRKGAAL QHLTKGGHFL AIGHDPQPQS IYNNPALYPL MFPWLFPYGL
GGVGQDYHKG LISRETHLQW LLMYYDKRFQ RDPNFVIVAF NQQMIRQSTS GSFMMMKRSN
FDNFVLSMNE LDPSVLASLA TRMREGEFVV PQTPEEKRCF SMLDQIDYIG SRVDGSLSQK
KFQRNELWSM ISFLNTPYFF ITVTPIDNKH PLCLYLAGTD EVFRPEIRLP ADRIRIISQN
PVACARFFDY MVRLFIQHIC GWSEDDPEKM GIFGKPSGYF GTVEQQGRLT LHLHFLLWIE
GAPSPQAVRD RLILDDKFRE KLIAYLESCQ VGECLTGTLD EVKSRFFNDE AERTDVIRSE
DSDDPTLTLP APPPDNFCLD DEDCTCERCI AMHTWYKEFE NTVDNILIRS NVTGVDVPKQ
HITGKGCVNE YGECTARFPR EIVLESKVNP TTGQISLKKK EAMMNNISPA ITYTSRGNTD
FTCLFSGTSV KATVGYVTDY VTKPMLKTHQ LFSALYDVFS TDAKTDGEDV KARDHVRKSL
LRVVNSLTSK MEIGAPYAAL RLLGLPDRYV SHQFVLFYAK NYINYVATHT DLQSTIENPI
ETDDEDVDDD EDDQDVGIQR VKGYGFQKPD ISAPKPGDEN VQVVSTSKRI YNKSNTEDYR
LRPPQHEHVS VYEWTQCSIK HYVGGGQPPP SGLHFFLFME DHPQYSTHVV ACDPARRNYI
IPNFRGPALP RSDEGDREEY CLAMLTLFKP WRTGVDLKPS TLSWDDAFNE HAFTKREIDL
MANFNVKYEC YDAKDDFYAM REHLREGIPE GVDPDDDNGA YLDVVEGGDM DFDDSIPEPG
ALTQAMKIQT KTALEDLTSA GWANAVPRPI TEPMPTMTLN IDETMTSADW TNIINVEKKR
IAAERLASLK LFTSSYGSLF DGSGEIMNDV YVVPGSYISR NFVPAIENDA NIINSIVAEN
GLNVEQERAF RIVANHSTCI GEKQLLMYLG GMGGTGKSRV IKAWVSYFER RNEAHRFVLL
GPTGTSAALI GGQTYHSFLG VNKFSGNNVQ SIEDLKERLI GVSYLIIDEM SMLSCMDLYA
INTKCQSALD SLELPFGGLN IILAGDFAQL PPVDGFPLYS RKVSSNATTP SQQLNYLGKM
TWMQFTTVVI LQQNMRQQQM TDKDEKLRTC LQNMRVKSCT PKDFEFLDSL IATQHRSLAE
LNEWEFRFTP IITATNIDKD LYNDVLSDLF SAYHNQPLKT FYSIDRIATS PDGRRNPRKK
YKKGRRLAPK DQFDLWKQPP NTSKQVAATL KICLGMPVII RHNVATELCI TNGQEAVIVG
WTSSRLPGYR DCRTLDVLYV ELTNPPKQIQ IPGLPPNVVP LGRQTQNIQA RLTTDHILSI
SRSQIPVLPY FSITDFGAQG KGLFRYRADM YRCRNHQAMY VALSRTTSAD GVLILRSYSK
EKLCGGLDGS LRQEFRELHY LDTITELQYN NQLREGILDI TRRTTIANYR PWKGRHVEKS
WHPALQGEDS DVGTIDTLCD QEAPVFGSRK RKLDDTILES NKRHKTSDAS IPKTDDNQVA
LSCIIQPDPA PRNLTRPQTL YGPIWDIDDH SCAYDSWTFI LSSLWLDNRH AWMDLMHHST
LLRKIEECFQ SLMIGGHCGI NPTYFQLCTS ISAIHSYMEL IRETSVQNFV NNAHTSVCAC
PSCTGPMYTQ QSYGPALCFQ IINSPGIIMQ HVICVGPYSI KYKLHGIIYF SNAHFTCRAI
LSDNSVYFHD GLEGGNAVYD GHLGISMSLE DLNVCRSRTA SVALYIKESI GYDMT
//
