ID A0A409YYK7_9AGAR Unreviewed; 1291 AA.
AC A0A409YYK7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Vacuolar import and degradation protein 21 {ECO:0000256|ARBA:ARBA00029670};
GN ORFNames=CVT24_010573 {ECO:0000313|EMBL:PPR08112.1};
OS Panaeolus cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Galeropsidaceae; Panaeolus.
OX NCBI_TaxID=181874 {ECO:0000313|EMBL:PPR08112.1, ECO:0000313|Proteomes:UP000284842};
RN [1] {ECO:0000313|EMBL:PPR08112.1, ECO:0000313|Proteomes:UP000284842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2629 {ECO:0000313|EMBL:PPR08112.1,
RC ECO:0000313|Proteomes:UP000284842};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. {ECO:0000256|ARBA:ARBA00025178}.
CC -!- SIMILARITY: Belongs to the EAF1 family.
CC {ECO:0000256|ARBA:ARBA00008913}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPR08112.1}.
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DR EMBL; NHTK01000155; PPR08112.1; -; Genomic_DNA.
DR STRING; 181874.A0A409YYK7; -.
DR InParanoid; A0A409YYK7; -.
DR OrthoDB; 1334563at2759; -.
DR Proteomes; UP000284842; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR46459:SF1; E1A-BINDING PROTEIN P400; 1.
DR PANTHER; PTHR46459; E1A-BINDING PROTEIN P400-RELATED; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00573; HSA; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51204; HSA; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000284842}.
FT DOMAIN 489..561
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 897..948
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 58..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..333
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..611
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..798
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1035
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1150
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1291 AA; 141781 MW; 679473AC0D28F9AE CRC64;
MKISLCFSLW KNMTCKKSMS TIFILESDIK LGQSPLNASI SNLEEQEFLS ALHKTSLYQP
EPKPLSSASS DHADTKPPST SRATRSRSRA VELAQVSPPP MDSTEGPSTV EKLVQDVSVG
SVPTSPSPKM KSKSPEPRTD TSSKDEDDLD DLDLVHPSSP MSQNGGQPSV KGSSRTPPLR
RSPSAPPAIS EQEISPEVPA VTETNNVGLE ETPVKKGEEE EEEEEAKEDM DVDLIAQSDM
SDHAEKPVED DSAMEVDNDS AETAPSVEPA ADTGNNGIIV VSSDTDKALD AVEEQAQTHI
ATINPSVLSV SEPTPPPPPP PPPPPPPPTQ VPYVPVKITY PPSIHKAIQI PHTTPVEQPH
FTFESVVESK PVPSTQDGTS TKSISFDYPL PPLSLLPPEF TRKAKYAKRR RNPDKDVKRE
KDRDELPLGI HRWNASILAN PLWKRVARST KCLSTKEWSI AMTELKLMRT LERVERLKDE
GRWSFRQPKK QRGVGGLTKT HWDYLMDEMK WMRIDFREER RWKLVVAYNL AHAAVDWHSL
ETLEERLEAG ICVKWRPIVP REPSPPEAEE VPSQVQRPVP PQPLQQQTSF LGVDYGSDAD
DDEDMETDEQ QVIDSLEPNN PVADALEETE GLKLKSEDVD DPSSLDLHNL PNAPDSPMNT
LPTSDGDVLG SSTSIDGLKT SSSNPMLGDA STKSSSQSAN EDGESQSAFP KISKQQLAPV
REKIVYGGVS QVFLTMDDIA DVVNEELEST DLTNLNVLFP ELTPLTLLDV APPAPPPVDG
RKKGERRSDR DDPNRRIEDT TYTKLYPIGR FMYEKPTLLG PLQPAKRWKD DHWLPAPEIL
WTQDNDVWTR TGTEEVGVSN DLFEGRPSNT TSFGFPIQTS SFKDKDNRKR GACDIVWSAN
DDALLKSLVD RYSNNWALVA ECYNASRLTT PSDKRSPTEC AERWKERWGQ ERKIPLPDAA
APSQTLADDT GAGSAMTSGS QMTTRGVKRM ASSSVSSSAP PVIASGSEPK KRRRHLVLQE
GIRRLARRRQ ESAAKLATQR KSTGIHETHN QYNKLPKLSP AELGRMKAER DNQANQELAL
ARRRNEEFQR LRDQASRGQA SQPPQPPAKP STQPAPQAAQ VQPAQPAPPT PSIPQTTPPV
PTPHQATPPQ VAPVPHAQLA QLQQLQNRAN AAAGAAALGN RPTRLAATPN NRNIPQQMLL
QQARLQLGPQ GLGQIGLLQQ AQGAAGGVNG SFYGLPSNLT QEQILMIALT AQQQQVAQQQ
QQQQQQQQQQ SQGSSGNAGN NGSTNGFIPQ T
//
