ID A0A410DMI5_9CLOT Unreviewed; 503 AA.
AC A0A410DMI5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE Short=Gal-1-P uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE EC=2.7.7.12 {ECO:0000256|HAMAP-Rule:MF_00571};
DE AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
GN Name=galT {ECO:0000256|HAMAP-Rule:MF_00571,
GN ECO:0000313|EMBL:QAA30292.1};
GN ORFNames=C1I91_00535 {ECO:0000313|EMBL:QAA30292.1};
OS Clostridium manihotivorum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=2320868 {ECO:0000313|EMBL:QAA30292.1, ECO:0000313|Proteomes:UP000286268};
RN [1] {ECO:0000313|EMBL:QAA30292.1, ECO:0000313|Proteomes:UP000286268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT4 {ECO:0000313|EMBL:QAA30292.1,
RC ECO:0000313|Proteomes:UP000286268};
RA Tachaapaikoon C., Sutheeworapong S., Jenjaroenpun P., Wongsurawat T.,
RA Nookeaw I., Cheawchanlertfa P., Kosugi A., Cheevadhanarak S.,
RA Ratanakhanokchai K.;
RT "Genome Sequencing and Assembly of Anaerobacter polyendosporus strain
RT CT4.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:66914; EC=2.7.7.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001107, ECO:0000256|HAMAP-
CC Rule:MF_00571};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC type 2 family. {ECO:0000256|ARBA:ARBA00008706, ECO:0000256|HAMAP-
CC Rule:MF_00571}.
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DR EMBL; CP025746; QAA30292.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A410DMI5; -.
DR KEGG; cmah:C1I91_00535; -.
DR OrthoDB; 2293at2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000286268; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00571; GalP_UDP_trans; 1.
DR InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR InterPro; IPR005850; GalP_Utransf_C.
DR InterPro; IPR005849; GalP_Utransf_N.
DR NCBIfam; TIGR01239; galT_2; 1.
DR PANTHER; PTHR39191:SF1; DUF4922 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR39191; GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF02744; GalP_UDP_tr_C; 1.
DR Pfam; PF01087; GalP_UDP_transf; 1.
DR PIRSF; PIRSF006005; GalT_BS; 1.
DR PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00571};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00571}; Reference proteome {ECO:0000313|Proteomes:UP000286268};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00571}.
FT DOMAIN 22..233
FT /note="Galactose-1-phosphate uridyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01087"
FT DOMAIN 249..429
FT /note="Galactose-1-phosphate uridyl transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02744"
SQ SEQUENCE 503 AA; 57830 MW; DB7DF63FCFBD5882 CRC64;
MVINISKEIE SLLDYAIEKE LISPLDRIYT KNRLLEVLEL TEIDEYTENH KEKSLESILE
NILSFASDNG VLKDGGVVAK DLFDTKIMGC LIGRPSEIIE KFNSLYEQDN KKATDYFYNL
SRHSNYIRWD RVQKDLKWKV NTEYGDIDIT INLSKPEKDP KAIALAKNMP SSSYPKCLLC
RENEGYAGRI NHPARQNHRI IPLNLNSEDW YLQYSPYVYY NEHCIVFKGS HEPMKIGKES
FVRLLQFVDK FPHYFLGSNA DLPIVGGSIL THDHFQGGNY EFAMATADTE KTYVVKGFED
MSVARVKWPM SVIRLKGNSI ERLVELSDHI LNSWRQYSDE SVDIISFTGE TPHNTITPIV
RKKNGLFEVD LVLRNNRTSE EHPDGIFHPH RELHHIKKEN IGLIEVMGLA VLPARLKDEL
KSLEAYLIGE CKLESISKES ELYKHKSWAE DMISIYDDIS LGNVESIIRK EVGIKFAKVL
EHCGVFKRDE VGLSAFDKFV ASL
//
