ID A0A410GGL6_9BURK Unreviewed; 1152 AA.
AC A0A410GGL6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:QAA95418.1};
GN ORFNames=CKA81_02100 {ECO:0000313|EMBL:QAA95418.1};
OS Pollutimonas thiosulfatoxidans.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Pollutimonas.
OX NCBI_TaxID=2028345 {ECO:0000313|EMBL:QAA95418.1, ECO:0000313|Proteomes:UP000283474};
RN [1] {ECO:0000313|EMBL:QAA95418.1, ECO:0000313|Proteomes:UP000283474}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ye3 {ECO:0000313|Proteomes:UP000283474};
RA Park S.-J., Kim H.;
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP022987; QAA95418.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A410GGL6; -.
DR KEGG; pus:CKA81_02100; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000283474; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000283474}.
FT DOMAIN 624..785
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 806..960
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1152 AA; 128074 MW; D54712C699E39325 CRC64;
MATETTLPSS LPSTENVLNA LKPGQRHAQP RPPGSGDAWW LADLARTSGR PLVALCADPL
TAQRLAEEVL LFAPDLRVRQ LPDWETLPYD SFSPHQDLIS ERLRSLHALM QEGVDILTVP
VTTALYRLAP PAFLAAYTFS FKQGDALDEE GLRRQLTLAN YTHVTQVTAP GEFCIRGGLI
DLFPMGSVLP YRLDLFDNEI ESIRSFDIDT QRSLYPVKEV QLLPGREFPM DEEARTQFRA
RFREIFEGDP SRALPYKDIG NGIAFAGVEY YLPLFFEQTA TLFDYLPKQS AMVTLGDVSQ
AIQGFAQDTH SRYQFLKSDR ERPVLPPSQL FLDEQALFAG LKGFARLSLT EGEVHPDFEP
APNVAVARRA DDPLANLRAL LMRPEGRIAL CADSAGRRET LVQMLAEFQI APDSGCETLQ
DFLLSDSRFA LVVAPLSNGF AVVSQDLTLL TENDLYPSQA RTVRRGRRGQ EAISDVAAMV
RDLSELRAGD PVVHAQHGIG RYCGLVEMDL GEGLMEFLHL EYANASTLYV PVSQLHVIAR
YSGADPESAP LHQLGSGQWD KARRKAARQV RDAAAELLAL YAQRAAREGH RFKLPVNDYQ
AFAEGFGFEE TPDQAAAIEA VIDDMTSGRP MDRLVCGDVG FGKTEVALRA AFLAVMNGKQ
VALLCPTTLL AEQHAQTFSD RFADWPVRIV ELSRFRSGKE VTAAVEGLNQ GTVDIVIGTH
KILSKDVKFK RLGLVIIDEE HRFGVRQKEA LKALRAEVDV LTLTATPIPR TLGMSLEGIR
DFSVIATAPQ KRLAIKTFVR REDGSTIREA LLRELKRGGQ VYFLHNEVDT IQNRRARLEE
LVPEARIAVA HGQMPERQLE EVMKGFYQQR YNVLLCTTII ETGIDVPTAN TIVIHRADRL
GLAQLHQLRG RVGRSHHQAY AYLLTPGEDA MTSNAKKRLE AIQAMEELGA GFFLAMHDLE
IRGTGEVLGE SQSGNIHEIG FSMYSEMLNE AVRALKSGEE PDLDSPFSAL CEVNLHASAL
LPSDYCPDVH ARLGLYKKLS HAKNEDDLIM IQEELIDRYG KLPEAAQTLL ATHRLRLSAE
PLGIVKIDAN ESQASIHFSA KPNVEPMRII ELIQKRRDVR LFGQDKLKVE IKQGQQVAAR
IDAVKDVLRA LV
//
