ID A0A410PN43_9CLOT Unreviewed; 664 AA.
AC A0A410PN43;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=EQM05_08565 {ECO:0000313|EMBL:QAT40310.1};
OS Clostridium sp. JN-9.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=2507159 {ECO:0000313|EMBL:QAT40310.1, ECO:0000313|Proteomes:UP000287890};
RN [1] {ECO:0000313|EMBL:QAT40310.1, ECO:0000313|Proteomes:UP000287890}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JN-9 {ECO:0000313|EMBL:QAT40310.1,
RC ECO:0000313|Proteomes:UP000287890};
RA Ma S.;
RT "Draft genomes of a novel of Clostridium strains.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP035280; QAT40310.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A410PN43; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000287890; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000287890}.
FT DOMAIN 5..271
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 272..532
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 664 AA; 77266 MW; A47BD889D315EA7C CRC64;
MNKNVSLDYF QTKAVTSKSR NLLVVAAPGS GKTSVIINRA VYLVKDKGVN INNILVITFT
RNAAINMRNR YSAISGDVNT PFIGTFHSLF YKIFERHFGR IKIITNSEAY TVIKNTLNSF
SDNITEERVN EFLNYISIYK IQGRKSLNES IDFEIFIKCY EDYENYKHEN NLIDFDDLQT
KVYKLLKESS LILKKYSTTF KYILVDEFQD CDEMQINILQ LLNKNCSIFA VGDEDQCIYS
FRGSMPQCMV EFEKYFEKGV KAYLGINYRS TSGIVTASMK LIKNNKLRNN KTVKSFNKDE
SDINIINCMD NKHQCLKILD KINILSSSHC NNKTAVLYRT SAENKLLIDL LIKNKIEFQL
LGDNYNFYEN MICRDLISYL KLSIDFTDVE SFISIINKPY RYISKMNLQK LKNNKYKGDC
FDFICNLDIA NFQVKTLDKI KKLLKKCSKL DTQEAVNCIL YKINYYEYIK EFCIKYKREL
CDFDCIINEF LESCSVYNNI HDFIDYTLKV KEKIKSNNKS NVILSTIHGV KGMEFNSVLI
MNCIDGYLPH ERSIPNNIEE ERRVFFVAVT RAIENLYLYI PKSLKGSERK VSRFINECEL
HISEESCNEF EINQTVVHNS FGKGIVRSID KDTIKIEFSK GLIRQFDLNS LINNNLIKLS
ANNI
//