ID A0A411WUA2_9BURK Unreviewed; 759 AA.
AC A0A411WUA2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:GGY52185.1, ECO:0000313|EMBL:QBI00218.1};
GN ORFNames=EYF70_04650 {ECO:0000313|EMBL:QBI00218.1}, GCM10007387_37980
GN {ECO:0000313|EMBL:GGY52185.1};
OS Pseudoduganella albidiflava.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Pseudoduganella.
OX NCBI_TaxID=321983 {ECO:0000313|EMBL:QBI00218.1, ECO:0000313|Proteomes:UP000292307};
RN [1] {ECO:0000313|EMBL:GGY52185.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KCTC 12343 {ECO:0000313|EMBL:GGY52185.1};
RX PubMed=30832757;
RA Wu L., Ma J.;
RT "The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing
RT project: providing services to taxonomists for standard genome sequencing
RT and annotation.";
RL Int. J. Syst. Evol. Microbiol. 69:895-898(2019).
RN [2] {ECO:0000313|EMBL:QBI00218.1, ECO:0000313|Proteomes:UP000292307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17472 {ECO:0000313|EMBL:QBI00218.1,
RC ECO:0000313|Proteomes:UP000292307};
RA Miess H., Frediansyhah A., Gross H.;
RT "Draft Genome Sequences of Six Type Strains of the Genus Massilia.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:GGY52185.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KCTC 12343 {ECO:0000313|EMBL:GGY52185.1};
RA Sun Q., Kim S.;
RL Submitted (DEC-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; BMWV01000009; GGY52185.1; -; Genomic_DNA.
DR EMBL; CP036401; QBI00218.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A411WUA2; -.
DR KEGG; mali:EYF70_04650; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000292307; Chromosome.
DR Proteomes; UP000628442; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:QBI00218.1}.
FT DOMAIN 93..192
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 434..495
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 684..756
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 84468 MW; 08F16702D752AB66 CRC64;
MNLNSTESGI TERPVSRGRR SAARPDGDAG QPPAISTSPL AAPMTPAGVA TISHLTEKLA
EYMSEADLKK VKEAYRFSDE MHLGQVRKSG EPYISHPIAV AEICADWKLD AQALMAALLH
DVMEDQDVKK EELIERFGAP VAQLVDGLSK LEKIEFQSQI EAQAENFRKM LLAMASDVRV
ILIKLADRLH NMRTLDVMAP AKKQRIAKET MEVYVPIAHR LGLNNIYREL QDLSFSHLYP
LRYHVLAKAV KAARGNRREV VGKILDSVKN TLGMAGIHAE VYGREKTLYG IYKKMRSKHL
TFSQVLDVYG FRVVVDSFSN CYVALGTLHS LYKPMPGKFK DYIAIRKLNG YQSLHTTLIG
PYGTPVEFQI RTQEMHRTAE SGVAAHWLYK NSDANMTDMQ QRTHAWLQSL LDIQQQTGDS
AEFLEHVKVD LFPDSVYVFT PKSKIIAMPR GATPIDFAYA IHTGIGDHTV SVTINGEPAP
LRAELRNGDI VEVVTDPNSR PSPSWLSFVR TGKARSAIRH HLRTINLPES IGLGRQLLQQ
ALAGISISPD LPEPLVERLL NESSAKSMDE LYADIGIGKR MAALVARHIF GLLGGESASV
PIDHNSAADL DPVTIYGSEG VSVQLAPCCL PIPGDQIIGQ LRRDQGLQVH TSDCSVARRQ
RQKEPDRWIA VKWGTELNRR FDSRIRLLIN NEKGILARVA AEIGESDGNI TFVGMDEDND
HVLHQLRFTI QVKDRVHLAG LLRNVRKVTG VNRVSRERG
//
