ID A0A412L6J8_9FIRM Unreviewed; 655 AA.
AC A0A412L6J8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Formate dehydrogenase subunit alpha {ECO:0000313|EMBL:RGS76616.1};
DE Flags: Fragment;
GN ORFNames=DWX73_11810 {ECO:0000313|EMBL:RGS76616.1};
OS Coprococcus sp. AF21-14LB.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Coprococcus.
OX NCBI_TaxID=2292231 {ECO:0000313|EMBL:RGS76616.1, ECO:0000313|Proteomes:UP000285019};
RN [1] {ECO:0000313|EMBL:RGS76616.1, ECO:0000313|Proteomes:UP000285019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF21-14LB {ECO:0000313|EMBL:RGS76616.1,
RC ECO:0000313|Proteomes:UP000285019};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGS76616.1}.
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DR EMBL; QRVX01000064; RGS76616.1; -; Genomic_DNA.
DR OrthoDB; 9803192at2; -.
DR Proteomes; UP000285019; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF00037; Fer4; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000285019};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Selenium {ECO:0000313|EMBL:RGS76616.1};
KW Selenocysteine {ECO:0000313|EMBL:RGS76616.1}.
FT DOMAIN 1..78
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 78..117
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 139..172
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 182..211
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 219..274
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
FT NON_STD 354
FT /note="Selenocysteine"
FT /evidence="ECO:0000313|EMBL:RGS76616.1"
FT NON_TER 655
FT /evidence="ECO:0000313|EMBL:RGS76616.1"
SQ SEQUENCE 655 AA; 71625 MW; DD58BEE5E4A0280A CRC64;
MINVTINGME IQAKEGQTIL KAARENGIHI PTLCFLEGIN EIGSCRICVV EIEGRAGLAT
ACNTVVREGM KIQTDSEAVV EARKNTLHLL MAEHKTNCFK CIKNGACELQ ALAREYGIDV
PNFKASHGDV QHEPCAENPF LSYDPGLCIQ CQRCISTCAK ATGRHALSLE KNGARVYVKA
PFGEGWKESL CESCGNCAQA CPTGALVIKR RKDYRDWEVK KVRTTCPHCA TGCQMDLIVK
NGKIVDVQGA DGPSNHGLLC VKGRSGSFDF VDCEDRIRYP LIKNKETGEF ERATWDEALD
LVASKFTEIK KQYGGEALAG FACSRSTNED IYMLQKMVRT AFESNNTDNC ARVUHAPTVA
GLATTLGSGA MTNTIYDITH ESDAIMLVGS NPEHAHPVLG MQVRQAVQRG AKLIVVDPRD
IDLCKDADIH LKLKPGTNVA FANGMMHIFI EEDLVDHKFI EERTENFEAM KELVKDYTPE
KVAEICGIDA DALREAARIY ATANRAPIMY CLGVTEHHTG TEGVMSLSNM AMMVGKIGKP
GCGVNPIRGQ NNVQGACDMG ASPNQFSGYQ NIDKPGVLEK FEEAWGTKLN PNIGTKATDC
FPKMLTGEVK GLFIFGEDPV RTDPNTHHVI KALSSLDFFV VDELFMTETA KGTTG
//
