ID A0A413G6V3_9FIRM Unreviewed; 1188 AA.
AC A0A413G6V3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=addA {ECO:0000313|EMBL:RGX56432.1};
GN ORFNames=DWV16_02095 {ECO:0000313|EMBL:RGX56432.1};
OS Anaerotruncus sp. AF02-27.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Anaerotruncus.
OX NCBI_TaxID=2292191 {ECO:0000313|EMBL:RGX56432.1, ECO:0000313|Proteomes:UP000284135};
RN [1] {ECO:0000313|EMBL:RGX56432.1, ECO:0000313|Proteomes:UP000284135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF02-27 {ECO:0000313|EMBL:RGX56432.1,
RC ECO:0000313|Proteomes:UP000284135};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGX56432.1}.
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DR EMBL; QSBX01000002; RGX56432.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A413G6V3; -.
DR Proteomes; UP000284135; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 6.10.250.2380; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:RGX56432.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000284135}.
FT DOMAIN 4..471
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 472..775
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1188 AA; 131968 MW; A24EE13E9FB54BCA CRC64;
MAEKRWTPEQ QNAISARGGT VLVSAAAGSG KTAVLVERVV GLLLDEDHPV DADRLLVMTF
SNAAALEMKQ RIMARVSDML AVHPDDEQLL RQQLLLGRAQ IGTVHSFCIS LIRENFQLLG
ISPNLRVADE KELEILRRDC ASGTVERFHS ERGAAFAELV ELLSSGRDDS RLFSTLFSLY
DFVRAHPFYR SWLDEKLGYY SPSVRVADSI WGQAILSYTA EAFDYAIQLT RQALGIITTD
EAMAAAYLDA FSHDLLQLEQ AAAIAARRDW DGVCEKLAAF TFDKLRPLKG DSPQKGSVQG
LRRAVKGIVD GLSKGQFCAT AAEFAEDIAF LKPMVEMLFD LVKEFDDDFT RQKLQRNLMD
FSDMEQYAIA LLVRTVGAGY AKTPLAENIS ALYDEVLVDE FQDTNEAQEI IFRAVSRDET
NLFMVGDVKQ SIYRFRQAMP ELFLEKKKRY APFDGAHFPA RITLGKNFRS APEVIGGINF
FFRLLMSEKI GELDYTDEEA LVPGAVFPPG VQEGVSLELL DVGEYAGERD KSAVEAGYVA
ERIAGLLEAG TLVSDGGGLR KVRPGDICIL MRSPSGKAQS YFDALTKLGV PVWSEPKSGY
LTTKEIAPVI SLLRVIDNPL LDIDLAAVMM SALFGFTADE MAALRLAKRR GPLYPALAAR
AGEGDLHCVA FLETLARLRQ FAAGATADQV IRKIYELTDY LGKVQVMRLG ETRRANLLLL
VQYACDYHAS GYKGLPGFVR FLDQLLERKS DLAPAASLSE QADVVRIMSI HRSKGLEFPV
VFLCDSAKRF NKEDLYGNTL LHSRLGFACV RRDFELMKQF TTVPMQALRL EIERSSLSEE
LRVLYVALTR AKERLYITGT VTKAEEKLAG YCAPLEADGR LSPYQVRAAS SYLDWLLMAA
VHHQDLLPAL AEIGVDVQTA PDESQLNLRI VPVLDDPDQE AKADEAGQAA PDPRLLTLLK
ERIAYRYPFE AQTRIPTKMA VSQISKGEMA KAYRFARRPA FLSASGLTGA QMGNALHKFM
QFADYAAAAK DAPAEIERMV ENGYLTRQEA DAVDAGKLNR FFSGTLAGRI FTAEKVYREL
RFLAEVGEET LGDYTGLFDG DSRTAIQGVA DCVFIEGGQA VIVDYKSDYV KEPQELIDRY
YGQLDLYRRV LGESLGMPVK ECVLYSFALG REIRLDFKKQ GVDSEEIL
//
