ID   A0A413I0D2_9FIRM        Unreviewed;       452 AA.
AC   A0A413I0D2;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN   ORFNames=DXA57_11170 {ECO:0000313|EMBL:RGY00149.1};
OS   Blautia sp. OF03-15BH.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=2292287 {ECO:0000313|EMBL:RGY00149.1, ECO:0000313|Proteomes:UP000285119};
RN   [1] {ECO:0000313|EMBL:RGY00149.1, ECO:0000313|Proteomes:UP000285119}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OF03-15BH {ECO:0000313|EMBL:RGY00149.1,
RC   ECO:0000313|Proteomes:UP000285119};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RGY00149.1}.
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DR   EMBL; QSCM01000009; RGY00149.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A413I0D2; -.
DR   OrthoDB; 9811110at2; -.
DR   Proteomes; UP000285119; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   InterPro; IPR048279; MdtK-like.
DR   PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR   PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000285119};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        21..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        141..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        171..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        277..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        394..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   452 AA;  49416 MW;  FF9CCAE7B6D1A38D CRC64;
     MENQHENPLG CEPINHLMAR FAIPSIIAML VSALYNMVDQ FFIGHSVGMQ GNAATNVAFP
     LTITCTAVSL LFGIGGAANF NLSMGRKKAE EAKHFIGNAI FLMLSFGICL CLVVCLFLNP
     LLKLFGATAD ILTYSQTYTS ITAFGFPFLI LSTGGSNLVR ADGSPRFSMT CTLVGCLVNL
     ILDPLFIFGF DMGMAGAAWA TIIGQIISAL MVIRYLTHFK TVKLTLKELK PRGYACGRII
     SLGMSPFLNQ LAIMIVQVVM NNVLVFYGSQ SVYGGEIPLA CAGIISKVNM IFFSISIGLS
     QGMQPIASFN YGAENYDRVR EAVLKTLTAS TLICTLAFLL FQLFPRQITG IFGSGSEEYF
     TFASRYFRIF LFFTFLNGIQ PVAGNFFTAI GKPVYGIFIS LTRQIIFLLP LILILPRFFG
     IDGVLYSAPI ADFLAACLAL FLTLRQLKKL SQ
//