ID A0A415EMD9_9FIRM Unreviewed; 646 AA.
AC A0A415EMD9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 08-NOV-2023, entry version 17.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN ECO:0000313|EMBL:RHK03399.1};
GN ORFNames=DW089_01725 {ECO:0000313|EMBL:RHK03399.1};
OS Acidaminococcus sp. AM05-11.
OC Bacteria; Bacillota; Negativicutes; Acidaminococcales; Acidaminococcaceae;
OC Acidaminococcus.
OX NCBI_TaxID=2291997 {ECO:0000313|EMBL:RHK03399.1, ECO:0000313|Proteomes:UP000285880};
RN [1] {ECO:0000313|EMBL:RHK03399.1, ECO:0000313|Proteomes:UP000285880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM05-11 {ECO:0000313|EMBL:RHK03399.1,
RC ECO:0000313|Proteomes:UP000285880};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHK03399.1}.
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DR EMBL; QRMX01000002; RHK03399.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A415EMD9; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000285880; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Endonuclease {ECO:0000313|EMBL:RHK03399.1};
KW Hydrolase {ECO:0000313|EMBL:RHK03399.1};
KW Nuclease {ECO:0000313|EMBL:RHK03399.1}.
FT DOMAIN 210..328
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 463..603
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 365..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 71161 MW; F13B9807150EC582 CRC64;
MSKKINLLDQ TTSNQIAAGE VVEKPASVVK ELVENALDAG ADQIDVTIFA GGTEFIRVKD
NGSGMDEENA RMAVLRHATS KILKADDLLT LHTLGFRGEA LPSIASVSHF SLLTREPGAE
FGTSLTLDGG ENMEVEPMGC DVGTTITVKD LFYNVPARRK FLRTVNTEGR YISEVITHMA
LSRPDVHFTL THNDKEVINT PGSGDVADTI SALYGGEVTK QLLTVDHEQD GIQVKGYISR
PTLLKGTRTW QTLFVNGRSI NNRMVSKAID HAYQSQIPKA GFPFAVLNIL VDTHSIDINV
HPQKSEIKFG DESAVYRAVY HALCKALTQP MAGRPEAGNT LAAAMPALAE EPQPAHVGLV
KEEAPLFTGG DRGREGRNQS FGSSTFASSS FPKNPAFGQQ VWKTPDVTQE ERENLYAAQR
RDEYAPNSSQ PLPSAYEAPL AQSQGEPGEA LPQGTSGVDV IWPLGQVDRV FIIAQSETAL
YLIDQHAAHE RIMYDRFIRQ QQEIPSQQLL IPLFLNVTKQ DVDAVEEYRE EFLKLGVDAE
PAGETVLRVS ALPADVEGSQ AEGFIDDILK LLSENKTIRP SDLREEVLHY AACHSAIRAG
EILNIRQMRQ VILELLNTEH PFTCPHGRPC MIKLTSQELY HMFKRT
//
