ID A0A415R3K9_9FIRM Unreviewed; 823 AA.
AC A0A415R3K9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 11.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:RHM53443.1};
GN ORFNames=DWZ54_10815 {ECO:0000313|EMBL:RHM53443.1};
OS Mitsuokella sp. AF33-22.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Mitsuokella.
OX NCBI_TaxID=2292047 {ECO:0000313|EMBL:RHM53443.1, ECO:0000313|Proteomes:UP000284511};
RN [1] {ECO:0000313|EMBL:RHM53443.1, ECO:0000313|Proteomes:UP000284511}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF33-22 {ECO:0000313|EMBL:RHM53443.1,
RC ECO:0000313|Proteomes:UP000284511};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHM53443.1}.
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DR EMBL; QRQA01000018; RHM53443.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A415R3K9; -.
DR Proteomes; UP000284511; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 553..756
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 823 AA; 88481 MW; A9548B32E9F692DE CRC64;
MRYGQHPERF FVSLLLALAL GILAGLAFLP ELQGWTGTLW LLVLLGSLLL AALAVWRQTA
LAWPCFLLLF FLLGAGRLQQ AVILPADDIS RFAGRTVNVA GRLTGEMKAV QDATGFRVSY
PLAVTGVRHG RGEWEQASGG VVLYGHTATR EEAEARIGDL VQSAGELRLI HGYQNPGQID
TALLRREEGI TANVFTGKNK IVVKAEESAP LLRLAAGVRQ HYREAMQQVM PPQDAAAIFA
LLFGGYDGLD PELVESFTIT GLIHILSVSG SHISLVAAAI AGICLLLRLP MACSAVLVTT
AIGFYALLAG FVPPVVRAAV MGGLTFLALA LGRERDSRHI LLLTGLAMLL YSPLLLFHIS
FELSFLATAG LLYLAPVFHR WLRARRIPAA ISLGLSITLA AQLATLPVLA WYFQRVSIVA
LLANLVVTPL LDVLILLGLL SGLVALLLPT AGGMLFAGCS LLLGLASEMT RWLAALPFSV
AVVPAFPFWA VLLFYLLLFL PALSAEWRGQ LAAFLRRESL AAGLLLLGLG TFLAIGHCMA
SRELTVHFID AGQGDAALVM TPSGKAVLFD AGGKRMGSFD IGERVTLPYL RHYGVRRLEA
VFLTHAHEDH AQGCGAILHA LPVGAVYTAG EGRDAYARSM RLGDNDPVLS RLQPVTRGQR
FELDGLTIEV LHAPQAAEEG DKRGNEASNV YRLRYGDASF LITGDLTAEG EAGLLACGAD
VRATVLKVAH HGSRTSTSEA FLQAAHPAYG VICAGRDNSF GHPHAEVVAR LQQHEVKILR
TDRDGAVVFA TDGRRLRIST YREQSLTARL EQSVLYQQTG PVS
//
