ID A0A415R6Z2_9FIRM Unreviewed; 722 AA.
AC A0A415R6Z2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 12.
DE SubName: Full=PTS glucose transporter subunit IIA {ECO:0000313|EMBL:RHM54808.1};
GN ORFNames=DWZ54_07515 {ECO:0000313|EMBL:RHM54808.1};
OS Mitsuokella sp. AF33-22.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Mitsuokella.
OX NCBI_TaxID=2292047 {ECO:0000313|EMBL:RHM54808.1, ECO:0000313|Proteomes:UP000284511};
RN [1] {ECO:0000313|EMBL:RHM54808.1, ECO:0000313|Proteomes:UP000284511}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF33-22 {ECO:0000313|EMBL:RHM54808.1,
RC ECO:0000313|Proteomes:UP000284511};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHM54808.1}.
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DR EMBL; QRQA01000010; RHM54808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A415R6Z2; -.
DR Proteomes; UP000284511; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00212; PTS_IIB_glc; 1.
DR Gene3D; 2.70.70.10; Glucose Permease (Domain IIA); 1.
DR Gene3D; 3.30.1360.60; Glucose permease domain IIB; 1.
DR InterPro; IPR011055; Dup_hybrid_motif.
DR InterPro; IPR036878; Glu_permease_IIB.
DR InterPro; IPR018113; PTrfase_EIIB_Cys.
DR InterPro; IPR001127; PTS_EIIA_1_perm.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR013013; PTS_EIIC_1.
DR InterPro; IPR001996; PTS_IIB_1.
DR NCBIfam; TIGR00826; EIIB_glc; 1.
DR NCBIfam; TIGR00830; PTBA; 1.
DR PANTHER; PTHR30009; CYTOCHROME C-TYPE SYNTHESIS PROTEIN AND PTS TRANSMEMBRANE COMPONENT; 1.
DR PANTHER; PTHR30009:SF24; PTS SYSTEM, IIBC COMPONENT; 1.
DR Pfam; PF00358; PTS_EIIA_1; 1.
DR Pfam; PF00367; PTS_EIIB; 1.
DR Pfam; PF02378; PTS_EIIC; 1.
DR SUPFAM; SSF51261; Duplicated hybrid motif; 1.
DR SUPFAM; SSF55604; Glucose permease domain IIB; 1.
DR PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
DR PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
DR PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW ECO:0000313|EMBL:RHM54808.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..432
FT /note="PTS EIIC type-1"
FT /evidence="ECO:0000259|PROSITE:PS51103"
FT DOMAIN 463..544
FT /note="PTS EIIB type-1"
FT /evidence="ECO:0000259|PROSITE:PS51098"
FT DOMAIN 594..698
FT /note="PTS EIIA type-1"
FT /evidence="ECO:0000259|PROSITE:PS51093"
FT REGION 546..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 485
FT /note="Phosphocysteine intermediate; for EIIB activity"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00421"
SQ SEQUENCE 722 AA; 76590 MW; 11D6E638688CDA38 CRC64;
MKDEIFSVLQ RVGRSFMLPV AVLPIAGILL GIGASFTNPT TIKTYGLEAI FGDGTILGGL
LTIMASAGST IFGNLPIIFA VGVAIGMAKA EREVAALAAM IAFFVMHSAC NAMLKLNGQI
LPDGSIAPGV LEGTIASSCG IMSYQMGVFG GIIVGIGVAY LHNKFHKIVL PNALSFFGGS
RFIPIISTVV YLFVGIALYF IWPIAQDGIF ALGSLVTGTG YIGTLIFGII KRALIPFGLH
HVFYLPFWQT GVGGSMMIDG QLVQGGQNIF FAQLASPNVT HFSADATRYF SGEFIFMIFG
LPGAALAMYR CAKPSKETAA KGLLLSAALT SMLTGITEPI EFSFLFVAPA LFGVQVVLAG
AAYMIAHMLN IAVGLTFSGG LLDLFIFGIL QGEAKTNWMY IIPVGIIYFF LYYFIFTWMI
KKFDFKTPGR EDDDEETKLY TKADYQAKKG AGANGGSQQS VEDAKSSMIA RGLGSKKNIT
SVDCCATRLR CSVADSSLVN EKILKATGAV GVIVKGTGVQ VIYGPQVAVI KANLETYLET
APEVEPELDA PAAEPAKEET APAAPAEAAA PKAASHALYA PVAGSVHPIT EAPDEAFAGK
MMGDGFFVYP SEETVYAPED GEVVFVFDTK HAIGMKAADG TEYLLHIGVD TVALGGKGFE
VFVEAGQKVK KGDKLMHFDD AYIKEHAKSD ACLVIYTGLQ EGQSVTMETT GDVKALAEVA
KF
//
