ID   A0A415R7G0_9FIRM        Unreviewed;      1063 AA.
AC   A0A415R7G0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Multidrug efflux RND transporter permease subunit {ECO:0000313|EMBL:RHM54823.1};
GN   ORFNames=DWZ54_07600 {ECO:0000313|EMBL:RHM54823.1};
OS   Mitsuokella sp. AF33-22.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC   Mitsuokella.
OX   NCBI_TaxID=2292047 {ECO:0000313|EMBL:RHM54823.1, ECO:0000313|Proteomes:UP000284511};
RN   [1] {ECO:0000313|EMBL:RHM54823.1, ECO:0000313|Proteomes:UP000284511}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF33-22 {ECO:0000313|EMBL:RHM54823.1,
RC   ECO:0000313|Proteomes:UP000284511};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHM54823.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; QRQA01000010; RHM54823.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A415R7G0; -.
DR   Proteomes; UP000284511; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004764; MdtF-like.
DR   NCBIfam; TIGR00915; 2A0602; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        340..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        392..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        539..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        875..893
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        900..918
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        938..959
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        992..1011
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1023..1046
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1063 AA;  114156 MW;  E4DE13893D68A03E CRC64;
     MSKFFIHRPI FAIVISLIIV IAGSIAATQL PIAQYPQISP PTVSVNTTYT GASASVVNQT
     VAQIVEDQVN GTQGMDYMSS SSDDTGRYSL SVTFNVGTDG DMDSVKVQNN VATATSQLPS
     EVQQVGLTTK KSSNDMAYMM AFYSPDGMYD RAFMKNYATI YLLDKLKRID GVGEVQVFGS
     DYAMRVWLNP DRLAELGLTV ADVTAAIKEQ NVQAPAGTVG AMPVNNGQEK QMSGKIDGRL
     TTPEEFGNVI IKSNGDGQFV RLKDVSRIET GSQSEAIISK FKGYPAVGFG VKLTSDANAM
     KTIGEVRKVF EEAQATLPPG MEMSTIFDST SYISASIEEV MMTFFEALLL VVFVIFIFLQ
     NWRATIIPLL AVPVSLIGTL GAFIILDFTI NTLTLFAMVL AIGLVVDDAI VVIENVEKHM
     EEGLTPVDAT ERAMDEVQGP VVAIAVVLSA VFVPVAFLGG MTGVLYKQFA LTIAVSVCLS
     AFVALTLTPA LCAMMLKKHT EKDDEGILGR FFVKFNNWFE RTKRGYVGVV AKFIRHTRLA
     LIFLLIVAGC AGIIFQKLPS TFVPNEDQGY LFAAVEMPDG TSANRTQEVI DRLNTALMGS
     VKGLDSTMAI TGFSPLSGGS SSSAGMIVIG MKDWSQRTDA DASVDAAVRT AFGIGAKVAP
     EATVIAMNPP ALPGLGMTGG WTLQLQDMTG HSETELNDIT KKIVAEANQR PELAGVRSTY
     SVGSPVIQYE VDREKVKNLG ITLSDVFTAM QVNYGGYQVN DFNRFGRSYK VMLQADNDYR
     STSDAMRFIF VKSSSGTMVP LDTLLRPKLT SGPSTISRFN GTRSIQITGQ TGNGYSSGQA
     MNAIKEVVQQ NAGTGFNIEW SGQSREEAKA SNSTMQVLAL ALVFVFLCLA ALYESWSVPF
     AVLLTVPTGI FGALVSEYGL SILEAMFGHQ NAGLQDSVYM QIGIIAIIGL AAKNAILIVE
     FAKVRVDRGM EPVKAALEAA GLRLRPILMT SFAFIIGCIP LAVATGAGAA ARNGMGVAVV
     GGMLFATAMG IFLIPVFFVA MEWIAAKLGL VKQERKKSTA DYM
//