ID A0A415WZ60_9FIRM Unreviewed; 817 AA.
AC A0A415WZ60;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=ATP-dependent DNA helicase {ECO:0000313|EMBL:RHO30059.1};
GN ORFNames=DW183_10315 {ECO:0000313|EMBL:RHO30059.1};
OS Roseburia sp. AM16-25.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=2292065 {ECO:0000313|EMBL:RHO30059.1, ECO:0000313|Proteomes:UP000286373};
RN [1] {ECO:0000313|EMBL:RHO30059.1, ECO:0000313|Proteomes:UP000286373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM16-25 {ECO:0000313|EMBL:RHO30059.1,
RC ECO:0000313|Proteomes:UP000286373};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. DinG subfamily.
CC {ECO:0000256|ARBA:ARBA00038058}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHO30059.1}.
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DR EMBL; QUCW01000004; RHO30059.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A415WZ60; -.
DR OrthoDB; 9765586at2; -.
DR Proteomes; UP000286373; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.275.40; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 1.10.30.20; Bacterial XPD DNA helicase, FeS cluster domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR042493; XPD_DNA_FeS.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF47; FANCONI ANEMIA GROUP J PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:RHO30059.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000286373}.
FT DOMAIN 218..485
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT DOMAIN 623..781
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 817 AA; 95330 MW; D715F0653DED5E72 CRC64;
MKISRLLQEE ELKPQIVISV RNLVEFLMNA GDIDDRHGGQ MRMEAMQEGS RIHRKIQRRA
GADYHAEIPL KFIVSYEEYD LAIEGRADGI IYEEGLLEET SRFLEDPRMD LEEGQEEAKP
FVMIDEIKGV YLDVEQMAEP NAVHLAQAKC YAFIFATQHA LPAIGVQMTY CNLDTEEIRR
FQMHYSYDEI ESWFLELVAS YKKWSDFLFH HKMIRQQSIR GLEFPYAYRQ GQKKLVTDVY
RSIMREKTLF LQAPTGTGKT LATIFPAIQA MGQNMGDKIF YLTAKNATGV VAHDTFLLME
EQGYEGKTVV ITAKDKMCLL EERSCNPDDC PYAKGHFDRV NDAVYDILQE ENMMDRDCIL
RWAKDRRVCP FEYSLDIASW VDHIICDYNY VFDPNVCLKR FFAEGIRGDY LFLVDEAHNL
VERARDMYSE TLVKEDFLAM KKKLKIYGKK LENTLERCNK EMLVLKRQCE KLLVLEEMDS
FLFALFRAAA AMDELLQKEG NIIDRDVVLD FYFKVRNFVN LSDDFDEHYR IYCDYDEKGQ
FCLHLFCVDP SYMLQKRLDR SRACVFFSAT LLPIRYYKEL LCCDDDVYAI YADSVFEQEK
RALLIGRDVS SRYTRRTFAE YLAFADYIEA IVEKKKGNYM VFCPSYKMLE EISQKFMAKS
LGSCDVICQR SGMSEQERED FLKEFEEVRE RSFVAFCVMG GVFSEGIDLT EEKLIGAIIV
GVGLPQIGNE REVMKQYFEA TGRDGFSFAY LYPGMNKVIQ AAGRVIRTKS DEGVIALLDE
RFTKSEYRQT FPREWNDGKI CDRHTVGDLV DDFWQKR
//
