ID   A0A415X3Y4_9FIRM        Unreviewed;       459 AA.
AC   A0A415X3Y4;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=MFS transporter {ECO:0000313|EMBL:RHO31729.1};
GN   ORFNames=DW183_04275 {ECO:0000313|EMBL:RHO31729.1};
OS   Roseburia sp. AM16-25.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=2292065 {ECO:0000313|EMBL:RHO31729.1, ECO:0000313|Proteomes:UP000286373};
RN   [1] {ECO:0000313|EMBL:RHO31729.1, ECO:0000313|Proteomes:UP000286373}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AM16-25 {ECO:0000313|EMBL:RHO31729.1,
RC   ECO:0000313|Proteomes:UP000286373};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC   -!- SIMILARITY: Belongs to the sodium:galactoside symporter (TC 2.A.2)
CC       family. {ECO:0000256|ARBA:ARBA00009617}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHO31729.1}.
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DR   EMBL; QUCW01000002; RHO31729.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A415X3Y4; -.
DR   OrthoDB; 9764596at2; -.
DR   Proteomes; UP000286373; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   CDD; cd17332; MFS_MelB_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR039672; MFS_2.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001927; Na/Gal_symport.
DR   NCBIfam; TIGR00792; gph; 1.
DR   PANTHER; PTHR11328:SF24; INNER MEMBRANE SYMPORTER YICJ-RELATED; 1.
DR   PANTHER; PTHR11328; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13347; MFS_2; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286373};
KW   Symport {ECO:0000256|ARBA:ARBA00022847};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        184..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        236..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        302..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        326..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   459 AA;  51326 MW;  6CA58AD5718078A6 CRC64;
     MKETRPFSMK DKIGYTLGDL GCCCTEQFRA MYLAIFYTLV LKVNPVHVGI LMLVTKLWDA
     INDPLIGALV DSHKNTGKGK FIPWIKFFAF PTAVLCVLGF VNVSNFAYGA RLAYMFITYV
     VYEIMYTCVN VPFGSLSSVM TDDVNQRTDL SRYRSLGGTI FMTVIVIAGP LFLYKDNQPV
     PSHFLMMAAV CAVIGFICLM ITANWCKERV ITEPIKEEKE KLNYLQVLKD ITKNKALLGV
     MLSSFIGIVG AGMVNGLNTY LFRDYFGNVA IMAISGMLSV LWSLIAFVGI KFVAKKFGKK
     EWIMYSATFS VVVFAILFFF PMKNPLLFII INGICYLGVS GFQVLIWALV NDAIDYQELQ
     TGKRNEGIVY SAYTFFRKLA NAVSGSMSSF ALAIAGFNVN LEVQSDAFAG HLWKTYTGLY
     VVGYLLAVLV LKFVYPLTKE KTEEMLHQLA DKRNAANAE
//