ID   A0A415X7N8_9FIRM        Unreviewed;       450 AA.
AC   A0A415X7N8;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN   ORFNames=DW183_01055 {ECO:0000313|EMBL:RHO33076.1};
OS   Roseburia sp. AM16-25.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=2292065 {ECO:0000313|EMBL:RHO33076.1, ECO:0000313|Proteomes:UP000286373};
RN   [1] {ECO:0000313|EMBL:RHO33076.1, ECO:0000313|Proteomes:UP000286373}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AM16-25 {ECO:0000313|EMBL:RHO33076.1,
RC   ECO:0000313|Proteomes:UP000286373};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHO33076.1}.
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DR   EMBL; QUCW01000001; RHO33076.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A415X7N8; -.
DR   OrthoDB; 9776324at2; -.
DR   Proteomes; UP000286373; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   CDD; cd13138; MATE_yoeA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR   PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   4: Predicted;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286373};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        20..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        97..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        195..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        418..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   450 AA;  48726 MW;  ACB4D62C88C539DC CRC64;
     MKANKKEVDM IHGPLLGKMI AFTIPVILSG VLQLLFNAAD IIVVGRFAGN ESLAAVGSTS
     SLINLLVNLF MGLSVGANVT VAFYFGCDHR EKVRDTIHTS ITLSLVCGVF LSIFGMLTSH
     QLLVWMGSPD DVIGLATTYL QIYFLGMPAL LTYNFGAAIL RAIGNTRTPL YFLMASGIVN
     VVLNLVLVIG FSMDVAGVAT ATVVSEYISA ALVLYYLHKQ SDVMHFSFKY LGIKTDVLGR
     IIRIGLPAGI QGTVFSLSNV VIQSAINSFG STVIAGNSAA SNIEGFVYMA MNAVSQTAVT
     FTSQNFGAGD KGRIKKVMFL CLGIVVAVGL ITGESAYLFG RQLLHIYTDS QPVVEAGLVR
     MSYICTTYFL CGMMDTMVGC LRGIGKSILP MIMSIVGACG LRLVWIATIF QIRHTEGILY
     MAYPITWAIT LSAHIITYVI CFKRMRYKNF
//