ID   A0A416GI35_9BACE        Unreviewed;      1879 AA.
AC   A0A416GI35;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0000259|SMART:SM01360};
GN   ORFNames=DXA74_01680 {ECO:0000313|EMBL:RHP67005.1};
OS   Bacteroides sp. OF04-15BH.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=2292281 {ECO:0000313|EMBL:RHP67005.1, ECO:0000313|Proteomes:UP000284249};
RN   [1] {ECO:0000313|EMBL:RHP67005.1, ECO:0000313|Proteomes:UP000284249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OF04-15BH {ECO:0000313|EMBL:RHP67005.1,
RC   ECO:0000313|Proteomes:UP000284249};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHP67005.1}.
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DR   EMBL; QUEM01000002; RHP67005.1; -; Genomic_DNA.
DR   OrthoDB; 9767116at2; -.
DR   Proteomes; UP000284249; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF136; ALPHA-2-MACROGLOBULIN HOMOLOG-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000284249};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..1879
FT                   /note="Alpha-2-macroglobulin domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018981850"
FT   DOMAIN          1129..1219
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   1879 AA;  212938 MW;  3BB026D492192944 CRC64;
     MKTYKNIRLR FCSGALLLSF LLCQPVEARR YDRLWKQAFR YQEQGYSASA GKVVDKIQVK
     ALRENNRNQE MAAFLAATSF RQQISPDSFY IDFQELERRV LQAETPAERA VYASFAAEVC
     QNNQYRGQWR AWAEGDSLPI EYWSREDYRK RALYYHTLSL TDVSVLGEVR LKDYMPLVLP
     GETDRQFGHD LLHLIGCRAL AGMKSLNADP ALLQESVGKI LSVYREHKNR DAELYFLLDS
     IQMTPPKNWG AVSSEQRDSL LFASAEYRAY ADIMQRFADR PSVAEAYLRA SQMGFSTPEQ
     VRLLQTALDR YPRYKRISAL KNELKSLSQP YLSWVVDETG YPGDTISWTL AHRNIRDVEC
     RIYRITQSLQ DTLTRQPFEK VGKMLQKQGE LLETRKLVLK EEPSPYEYVR DTLSWTVPEI
     GYYALYFTVR SPEGTQEECR FFQSSTLRAF SLAEPDGRML DVLVTDARSG APRPMARVEV
     MSPSLEEDRQ LRITSYTDAY GRASLDISDF KQYKIYACWQ GDSIWLDPRG KERFATPKTT
     ETWGEIYTDR SLYRPGQTVH LAGVAGKRQS TTYQVMPDTR LPLSVYDVSG KEVYRDSVQT
     DAWGSWRMDY QLPQQGANGS YRVRVGEVSE NFSVEEYARP HFEIVLDQTD MAPKAWGDTL
     QVSGVVRNYN GAPAAYARVA AQFRISNIFA SSWENRSPVN DTLQTDATGR FCFSFPVGAS
     LNPDKPDYSY PASVSCTALH PSGEQAEQRA FLQVVTLRNK LSLEVPEVLN RDSVEQVCFH
     LNNTRNELLQ GTVFYQLVPA DGASSGAPVQ ATGKYIANKD FALEGLQGLP SGRYILKATS
     VVENDTLKAS RPVIVYSPKD TRVPADTVFW FRTLQPDFTE SKPFVCEVGS SEREVTLYYT
     LCHNGKIQER KVLEFSDSLF TLQLPYQSDY ADGASLHLAF VKDNKVYTRD IRINHRIETP
     RLHYKWHTFR DKLSPGAREK WTLQLTDSKG NPVEARCFFT LYDASLDAIR RHSWRLSPPS
     VPYLAMPSWN SRYLSVTSFG ISFPWKHELQ PAEIWSELNL QLLGGMPSGG KTKGAPLLYQ
     SAAGVSVNRM HSPKMLDEVV VAEVEESMDM AAAPSLETNP VIRKNLQETA YFNAELNTDK
     EGKVSLSFTV PEALTRWRLL GVGYTKDMAY CRIDTTVVTQ QQLMAQLFRP AYLNVGDQAR
     LQTTLTNLSD EADRGTLTLE IRDAETDSMV FREEQPFRIA GGESAQYTFD FVPEQGNRTL
     VCRILADGQH HSDGEQQYLQ VLPATVPVTY ARPFVVEGSG VHQIGLPVQD AYRRQGLSPS
     SWFLEYNTNP LFAAVQVLPL LQNTESRGAE ELVAGYYATV CSAHLLKTRP QIGDWLKHWN
     DPEYLRYEDE WWKWVRRLNP RLWEETPWSR SYEESGNRLA AVYAAQNDPA KIAEQRSRLL
     DGLLACQQTD GSFAWMPGLR GRSSVTLRVL SLLETLRPYS AALADEELNR KEQLLRDRAF
     RYLQKTFEER SVGVEPLSMA GSADETDFLW LAACHLGADE ARKLPAVKSA VEALARHSST
     LPYARKISAA RALHAYGYRD EALACLNSVA EHLVTDSLGA RYFDTTLAGE TAGEQRLLLH
     LAALQQFRTL QPEQKEPAQG MLRWVLLQKR IQGWDNNYLS ACAVQALLAD AAEAVPASAG
     DSLWLHTGTV RQGVAAAPAA LPVVRYVLPL DGKNGCPDAL TVKKQDDRLT WGTAYTQYDL
     SPDQIMRKQK EWGALSVEIS RMPDSLTVGQ DLNAVYMIRA DRDYDYMLLH LKSAACCRPA
     WLTSGYRSVQ GVGYYLSLEE DGMLLYFDHL PKGNYVLEVP YKVQFSGNYL HGGAEFQSYY
     APEFRTYLPG KKIKVNEAK
//