ID   A0A416JTJ0_9FIRM        Unreviewed;       406 AA.
AC   A0A416JTJ0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 11.
DE   SubName: Full=Cobalamin biosynthesis protein CobW {ECO:0000313|EMBL:RHQ16226.1};
GN   ORFNames=DW974_09655 {ECO:0000313|EMBL:RHQ16226.1};
OS   Lachnospiraceae bacterium AM48-27BH.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=2292271 {ECO:0000313|EMBL:RHQ16226.1, ECO:0000313|Proteomes:UP000285913};
RN   [1] {ECO:0000313|EMBL:RHQ16226.1, ECO:0000313|Proteomes:UP000285913}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AM48-27BH {ECO:0000313|EMBL:RHQ16226.1,
RC   ECO:0000313|Proteomes:UP000285913};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHQ16226.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; QUFC01000015; RHQ16226.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A416JTJ0; -.
DR   Proteomes; UP000285913; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13748:SF62; COBW DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR13748; COBW-RELATED; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000285913}.
FT   DOMAIN          6..179
FT                   /note="CobW/HypB/UreG nucleotide-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02492"
FT   DOMAIN          318..405
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07683"
SQ   SEQUENCE   406 AA;  45939 MW;  0000CE5ED6877935 CRC64;
     MTKIDIISGF LGAGKTTFIK KLLEEAIAGE QVVLIENEFG QIGIDGGFLK NSGIEIREMN
     SGCICCSLVG DFGKSLEEVL TKYQPDRVII EPSGVGKLSD VMKAVRDVAS TLDVVLNSAV
     TIVDASKCKM YMKNFGEFFN NQIENAGTVV LSRTDVVDAA KVQQDVELIR EHNASASIVT
     TPCSQLSGAQ LLEIIEKPDT MAEDLMREVE ERRAHEAEHD HEHHHHHHDD DDECECGCHD
     HDHEHHHHHD DDDDECECGC HDHDHEHHHH HDDDDDECEC GCHDHDHEHH HHDHDDDCDC
     GCHDHDHHHH HHHADEVFTS WGMENVAPCK KEELEAFLQD LSKGDVYGQV LRAKGMIPSE
     TEGEWYYFDL VPEEYEIRKG QPDYTGKVCV IGAKLDEEAL KKVFHK
//