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Database: UniProt
Entry: A0A417HPA1_9FIRM
LinkDB: A0A417HPA1_9FIRM
Original site: A0A417HPA1_9FIRM 
ID   A0A417HPA1_9FIRM        Unreviewed;       158 AA.
AC   A0A417HPA1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   13-SEP-2023, entry version 16.
DE   RecName: Full=Transcription elongation factor GreA {ECO:0000256|ARBA:ARBA00013729, ECO:0000256|HAMAP-Rule:MF_00105};
DE   AltName: Full=Transcript cleavage factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   Name=greA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   ORFNames=DW741_02785 {ECO:0000313|EMBL:RHT73960.1};
OS   Ruminococcaceae bacterium AM28-23LB.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae.
OX   NCBI_TaxID=2292269 {ECO:0000313|EMBL:RHT73960.1, ECO:0000313|Proteomes:UP000284026};
RN   [1] {ECO:0000313|EMBL:RHT73960.1, ECO:0000313|Proteomes:UP000284026}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AM28-23LB {ECO:0000313|EMBL:RHT73960.1,
RC   ECO:0000313|Proteomes:UP000284026};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting sites
CC       in DNA have the property of trapping a certain fraction of elongating
CC       RNA polymerases that pass through, resulting in locked ternary
CC       complexes. Cleavage of the nascent transcript by cleavage factors such
CC       as GreA or GreB allows the resumption of elongation from the new
CC       3'terminus. GreA releases sequences of 2 to 3 nucleotides.
CC       {ECO:0000256|ARBA:ARBA00024916, ECO:0000256|HAMAP-Rule:MF_00105,
CC       ECO:0000256|RuleBase:RU000556}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family.
CC       {ECO:0000256|ARBA:ARBA00008213, ECO:0000256|HAMAP-Rule:MF_00105,
CC       ECO:0000256|RuleBase:RU000556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHT73960.1}.
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DR   EMBL; QUJM01000003; RHT73960.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A417HPA1; -.
DR   OrthoDB; 9808774at2; -.
DR   Proteomes; UP000284026; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.50.30; Transcription elongation factor, GreA/GreB, C-terminal domain; 1.
DR   Gene3D; 1.10.287.180; Transcription elongation factor, GreA/GreB, N-terminal domain; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   NCBIfam; TIGR01462; greA; 1.
DR   PANTHER; PTHR30437; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR   PANTHER; PTHR30437:SF4; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF54534; FKBP-like; 1.
DR   SUPFAM; SSF46557; GreA transcript cleavage protein, N-terminal domain; 1.
DR   PROSITE; PS00829; GREAB_1; 1.
DR   PROSITE; PS00830; GREAB_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00105}; Elongation factor {ECO:0000313|EMBL:RHT73960.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:RHT73960.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000284026};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00105};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00105}.
FT   DOMAIN          6..75
FT                   /note="Transcription elongation factor GreA/GreB N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03449"
FT   DOMAIN          83..157
FT                   /note="Transcription elongation factor GreA/GreB C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01272"
SQ   SEQUENCE   158 AA;  17623 MW;  C2C11CCD9A198C61 CRC64;
     MQKQFMLTEE RLKEIKDELE YLKTVREKEV AEQIKEARSF GDLSENSEYD EAKNEQGKLY
     SRIAELENVI AGAVIINEDS ITTQHVSMGT RVTVVEEGFE DEPEEYAIVG SQEANPVQGR
     ISDESPLGKA LYGHGVGDTV VVEAPDGAIT YRIVAIDR
//
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