ID A0A417U0M4_9FIRM Unreviewed; 823 AA.
AC A0A417U0M4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 03-MAY-2023, entry version 15.
DE SubName: Full=HD domain-containing protein {ECO:0000313|EMBL:RHV46271.1};
GN ORFNames=DXB46_14490 {ECO:0000313|EMBL:RHV46271.1};
OS Lachnospiraceae bacterium OM04-12BH.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=2292272 {ECO:0000313|EMBL:RHV46271.1, ECO:0000313|Proteomes:UP000284430};
RN [1] {ECO:0000313|EMBL:RHV46271.1, ECO:0000313|Proteomes:UP000284430}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OM04-12BH {ECO:0000313|EMBL:RHV46271.1,
RC ECO:0000313|Proteomes:UP000284430};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHV46271.1}.
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DR EMBL; QULQ01000018; RHV46271.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A417U0M4; -.
DR OrthoDB; 1837345at2; -.
DR Proteomes; UP000284430; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR PANTHER; PTHR11528:SF97; ENDOPLASMIN; 1.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF01966; HD; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000284430}.
FT DOMAIN 46..291
FT /note="HD/PDEase"
FT /evidence="ECO:0000259|SMART:SM00471"
SQ SEQUENCE 823 AA; 95785 MW; 8BA46D907C841BA9 CRC64;
MIEKVQESHL YMWLKEKDSK FLSKLDETIE YANTILPQIN NVFASYTVHG VRHSINVMEY
MYALVVDINK LSELEVALLI YSALLHDIGM IANVDEIKEI KADHAILGER KYSKVLEKYG
DEMTALQECV RPVHGKRARD YIETKMDERL FLIPESTNIS FKSELAQICM SHNEDFEWIK
KNLHNDEKKG HFDLNTQYIS VLLRISDYLD IDEQRAPLYL YKYLNPKEFS DLEWKQHFVI
ENYDKIRRNP KTNELEIFFQ GTSQDPSVHR KLLKYFDAIN GELKNAVDLC ESFVDEKYLL
PLKTNVVNQI QSKGFSFSDL RLSLDYNAVT NLLMGEHIYG DRKYGLRELI QNSIDACKTM
EESATKMEKF RYQNYQPYIS VILDKDRKKV MVMDNGSGMS IDILKKYFLN VGVSYYASDD
YRLQDREYSP IGHYGIGFLA CFMLSDKVEV NTVYYNEQKM NRISFERNSE YICLTYEDTV
RQQGTEIILD YDQCLSVFNN NIERLVSFIE NNFLDCGIPI KISTMEKGVS MPLECNIKRI
ETIIAENICL SEYLSGIEAF IDCSYKQINF AKYLSDINGY ESYCYNEEEY SVDEENISIK
NFVKDGKITF LKIPIITEDE ESEFLKAYDV LEDYQEALDK IGNYEAINIW GDEDEFEDYD
FIIEESSESI IGGYTLGGFR NQFHHGSLTP VKPEIIKKGV VTGESNAVLP YNEENTFKGR
FSWENTDTCY VKNVLLSGLR IKIPYLVDGV ILKGAVINIF NREFIPNVSR NNISASQQEK
LSYAIGKAIH LWIRDHAELS TEQKALLDVF IETKYKETNY CLR
//
