ID A0A417UDS2_9FIRM Unreviewed; 574 AA.
AC A0A417UDS2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=DUF4080 domain-containing protein {ECO:0000313|EMBL:RHV51541.1};
GN ORFNames=DXB46_02175 {ECO:0000313|EMBL:RHV51541.1};
OS Lachnospiraceae bacterium OM04-12BH.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=2292272 {ECO:0000313|EMBL:RHV51541.1, ECO:0000313|Proteomes:UP000284430};
RN [1] {ECO:0000313|EMBL:RHV51541.1, ECO:0000313|Proteomes:UP000284430}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OM04-12BH {ECO:0000313|EMBL:RHV51541.1,
RC ECO:0000313|Proteomes:UP000284430};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHV51541.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QULQ01000002; RHV51541.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A417UDS2; -.
DR OrthoDB; 9801424at2; -.
DR Proteomes; UP000284430; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR025288; DUF4080.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF18; RADICAL SAM SUPERFAMILY PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF13311; DUF4080; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000284430}.
FT DOMAIN 1..135
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 167..397
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 574 AA; 67818 MW; D4816275B3CF0668 CRC64;
MKFLLVGINS KYIHSNPAIH YLKLYAGKEY QNTVELAEYT INHLKEQILS DIYRRRPDAI
GISCYIWNFR MVQELLPEIH KVLPGRDIWL GGPEVSFEGD EVLAQFPYVT GIMTGEGEET
FRELLSCYGD EKDYHGVKGL LLPDGFTGSR RELSMDELPF LYTDLQEYEN RILYYETSRG
CPFQCTYCLS SIERKVRLRS HEKVEQELSY FLAKKVPQVK FVDRTFNCNR EHALFIWNYI
REHDNGVTNF HFEVAADIMN EEQLAALAAM RPGLVQLEIG IQTTNDKTLH EINRYADTRH
IAGVVARLRE PGNIHIHLDL IAGLPYEDYE SFGRSFDEVY AMKPEQLQLG FLKVLKGSPM
YHMTEQYGIV YQSTPPYEVL YTKWLSFDEI LRLKRIEEMV ELYYNSNQFR KTLFMLEQAF
SGPFQMYSRL ADYYEEKGYF INTPARSYRY QVLLDFAMER EPEKADLYTE LLTCDYYLRE
NAKSRPSFAA DQTCYYREMA DFYEKEEKEP EILTEYEGYH AKQVMKMTHM EAFFYPVWEN
CPEKICERWE KPGFLLFDYE KRNPLTGDAR TVLI
//
