ID A0A417VJ93_9FIRM Unreviewed; 407 AA.
AC A0A417VJ93;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 12.
DE RecName: Full=Cobalt-precorrin-5B C(1)-methyltransferase {ECO:0000256|HAMAP-Rule:MF_00787};
DE EC=2.1.1.195 {ECO:0000256|HAMAP-Rule:MF_00787};
DE AltName: Full=Cobalt-precorrin-6A synthase {ECO:0000256|HAMAP-Rule:MF_00787};
GN Name=cbiD {ECO:0000256|HAMAP-Rule:MF_00787,
GN ECO:0000313|EMBL:RHV68245.1};
GN ORFNames=DXB15_11170 {ECO:0000313|EMBL:RHV68245.1};
OS Roseburia sp. OM02-15.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=2292368 {ECO:0000313|EMBL:RHV68245.1, ECO:0000313|Proteomes:UP000285983};
RN [1] {ECO:0000313|EMBL:RHV68245.1, ECO:0000313|Proteomes:UP000285983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OM02-15 {ECO:0000313|EMBL:RHV68245.1,
RC ECO:0000313|Proteomes:UP000285983};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to
CC form cobalt-precorrin-6A. {ECO:0000256|HAMAP-Rule:MF_00787}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A +
CC S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:26285, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:60063, ChEBI:CHEBI:60064;
CC EC=2.1.1.195; Evidence={ECO:0000256|HAMAP-Rule:MF_00787};
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC step 6/10. {ECO:0000256|HAMAP-Rule:MF_00787}.
CC -!- SIMILARITY: Belongs to the CbiD family. {ECO:0000256|HAMAP-
CC Rule:MF_00787}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHV68245.1}.
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DR EMBL; QULX01000011; RHV68245.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A417VJ93; -.
DR UniPathway; UPA00148; UER00227.
DR Proteomes; UP000285983; Unassembled WGS sequence.
DR GO; GO:0043780; F:cobalt-precorrin-5B C1-methyltransferase activity; IEA:RHEA.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0046140; P:corrin biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2110.10; CbiD-like; 1.
DR HAMAP; MF_00787; CbiD; 1.
DR InterPro; IPR002748; CbiD.
DR InterPro; IPR036074; CbiD_sf.
DR NCBIfam; TIGR00312; cbiD; 1.
DR PANTHER; PTHR35863; COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR35863:SF1; COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE; 1.
DR Pfam; PF01888; CbiD; 1.
DR PIRSF; PIRSF026782; CbiD; 1.
DR SUPFAM; SSF111342; CbiD-like; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573, ECO:0000256|HAMAP-
KW Rule:MF_00787};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW Rule:MF_00787};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_00787};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00787}.
SQ SEQUENCE 407 AA; 43913 MW; A36C2F9CFC1CBCBB CRC64;
MKNGLENYFV IKDNKKMRFG YTTGSSAAAA AKAAAEMLFS GKDVPVVELL TPKGITLYLE
VLDAKGGQRT CSCAIQKDGG DDPDVTSGLR IYAKVTLCER QEAEAICQKF QQSEKSDLKA
VASVGITAGE GVGIVTLPGL EQSIGAPAIN RVPREMITKE VQAVCEKYHY TEGVEVCISV
PNGAVVAEKT FNPRLGIKGG ISILGTSGIV EPMSEQALIS SIQVEMKQKS AGDRKYLLIA
PGNYGLQYLS GNFPFEAEEA VKCSNYVGQT IDFAVNMGLK GVLFVAHIGK FIKVAGGIMN
THSREADARM EIMAACALRA GADADTANRI LVAVTTDEGL SILKETPYWV QTMQIITEKV
EYYLNHRAQG RLEIGAVLYS NAHGELGRTS LVEQLLEQLQ EQKSKEE
//
