ID A0A417XSE6_9ACTN Unreviewed; 1846 AA.
AC A0A417XSE6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=ATP-grasp domain-containing protein {ECO:0000313|EMBL:RHW23235.1};
GN ORFNames=D0Z08_30880 {ECO:0000313|EMBL:RHW23235.1};
OS Nocardioides immobilis.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=2049295 {ECO:0000313|EMBL:RHW23235.1, ECO:0000313|Proteomes:UP000283644};
RN [1] {ECO:0000313|EMBL:RHW23235.1, ECO:0000313|Proteomes:UP000283644}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC AB 2017083 {ECO:0000313|EMBL:RHW23235.1,
RC ECO:0000313|Proteomes:UP000283644};
RA Li C., Wang G.;
RT "Genome sequencing of Nocardioides immobilis CCTCC AB 2017083 for
RT comparison to Nocardioides silvaticus.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHW23235.1}.
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DR EMBL; QXGH01000053; RHW23235.1; -; Genomic_DNA.
DR OrthoDB; 3754062at2; -.
DR Proteomes; UP000283644; Unassembled WGS sequence.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866:SF126; BIOTIN CARBOXYL CARRIER PROTEIN; 1.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000283644}.
FT DOMAIN 4..458
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 127..325
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 578..661
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1562..1845
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
FT REGION 662..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1846 AA; 198662 MW; A85A79C8D78EE779 CRC64;
MTVSFERIAI VNRGEAAMRF IHAARDLRAA GERIETVALY TDVERNARFV READEAYPLG
PASARPYLDL ALLERALVET AADAVWVGWG FVAEEPAFVE LCDRLGVTFI GPSAEAMRRL
GDKIGAKLLA EEVGVPVAAW SGGPVETLRD ALTAAEAIGY PMMLKASAGG GGRGIRMVTS
PAELEEAYQR TRDEAERAFG SGVVFLERLV TGARHVEVQV IGDGHGTAWA LGVRDCSVQR
RNQKVLEESA SPLLTAEQAD DLKASAERLA VAVGYQGAGT VEFLYQPGEK AFAFLEVNTR
LQVEHPITEI TTDFDLVKAQ VHVARGGRLD DQPRPAESGH AIEARLNAED PDRDFAPSPG
RVARLELPSG PGVRVDTGLA EGDTIPADFD SMIAKVIAYG RDRDEALARL RRAMSETTVV
IEGGTTNKSF ILDLLDQPEI VSGAPAWADT AWIDRVRGEG RLTSQAHSGT ALVVAAIEAY
DEQRRVEVDR LLETGHGGRP QVQHKVGQPT DLKLRGTTYK VTALQTGPGR YRVTIAAGSV
VETADVEIAR IDEVHSRLLV NGRRHRIVSA THGPTHLVEV DGVTHRVGRD EGGVLRSPAP
ALVVATPAAV GDEVAAGAPV LVLESMKMET VIQAPFAARV RELLAVTGSQ VETGAPLVRL
EPVGDDGAEE SPQPADAAPA LDLPHDDMER TARQRADRHL ADLAALVQGY DVPRDDRVAA
LRSYLVAREE LRAAGEDVIA GEAELLALFT DFAELSRNRP AGEELRTELK VHSSREHFHT
FLRSLDTERG GLPEGFRQRL EQVLSRYGVA DLERTAVLEE AVFRIFLALQ RPAESVEVVT
ALLQRWIGEA PPSEGPDGNV RELLERLKQA TQLRFPAVGD LARSVRFRWF DQPLVDEERT
SVLAGVRDEV AALAADPQVP DRADRIDALA VIPEQIVRFL AERVERGASS GEWDDEPMLE
VLIKRHYRDF DLHGASASHH DGRPFAVADY VLDERPTRLV TTVGTVAELA EGSDLVAGLR
TELAARPEGT KAVLDLYLHW PLAPESIAAG RDELAAVLSG LGLAQDARRV TVAVCPGEGR
PVDYFTFRPD GSHGVEEDEL VHGVHPMVGR RLNLWRLRNF HVTRIEAPDD VLLYECVARE
NPADRRLVAL AQVRQLAVVH DEEGRVTALP HAERAVENCL EAIRRARTAR GAAGAKLDLN
HVWVQVWPVV EADIAQLTGL QQKITPLTDG AGIAEVLAQG RVAGPDGTAT PIAIRFHARP
GAGVVSSIEA PPTELLQPLD DYDSKVLRAR RRGLVYPYEL EAIVAGDGGT LVEHDLDDAG
ALVPVDRPRG LNKAGILVTV ASTPTALHPE GVTRVVLCGD PTKALGAVSE PECSRVIAAL
DLAERMGVPV EWFALSAGAR ISMDSGTENM DWVAAALRRI VEFTQAGGEI NVVVAGINVG
AQPYWNAEAT MLMHTKGILV MTPDSAMVLT GKQSLDFSGG VSAEDNFGIG GYDRVMGPNG
QAQYWAPDLS GACDVLMAHY EHTYVAPGES RPRDAATSDP ADRDVTTYPH SDPGSDFTTV
GQIFSPVSNP DRKKAFDIRT VMRALADQDH ATLERWAGMA DADTTVVFDA RLGGHPVCLL
GIESKPVPRR GFPPTDGPDV YTAGTLFPRS SKKAARAINA ASGNRPLVVL ANLSGFDGSP
DSMRNLQLEY GAEIGRAIVN FRGPIVFCVV SRYHGGAFVV FSKALNPQMT VLALEGSFAS
VIGGAPAAAV VFAGEVDKRT AADPGVTKLE AAIADASPSE RGPLVVELAE LKRALRAEKI
SEVAAEFDGV HDIHRAVSVG SVDAVIAPER LRPEIIAVIE RGLGEL
//