ID A0A417XTK9_9ACTN Unreviewed; 403 AA.
AC A0A417XTK9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE SubName: Full=Acetyl-CoA C-acyltransferase {ECO:0000313|EMBL:RHW23808.1};
DE EC=2.3.1.16 {ECO:0000313|EMBL:RHW23808.1};
GN ORFNames=D0Z08_27930 {ECO:0000313|EMBL:RHW23808.1};
OS Nocardioides immobilis.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=2049295 {ECO:0000313|EMBL:RHW23808.1, ECO:0000313|Proteomes:UP000283644};
RN [1] {ECO:0000313|EMBL:RHW23808.1, ECO:0000313|Proteomes:UP000283644}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC AB 2017083 {ECO:0000313|EMBL:RHW23808.1,
RC ECO:0000313|Proteomes:UP000283644};
RA Li C., Wang G.;
RT "Genome sequencing of Nocardioides immobilis CCTCC AB 2017083 for
RT comparison to Nocardioides silvaticus.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHW23808.1}.
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DR EMBL; QXGH01000040; RHW23808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A417XTK9; -.
DR OrthoDB; 4440515at2; -.
DR Proteomes; UP000283644; Unassembled WGS sequence.
DR GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:RHW23808.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000283644};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:RHW23808.1}.
FT DOMAIN 5..267
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 277..401
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 358
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 388
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 403 AA; 42585 MW; 0B4F64D4E41AD049 CRC64;
MREAVICEPV RTAVGKYGGV FKDVPAAELA ATVLRGLVER TGIDPGSVDD VIFGQCYPNG
EAPAIGRVAA LDAGFPISVP GQQLDRRCGS ALQAVLDGAM RVQTGACEVV VAGGAESMSQ
AEHYTVGGRF GYRGDSAPMW DRIARGRITS GGKNYPVEGG MLETAENLRR EFSISREAQD
QLAFSSHQRA VTAQRDGRFK EEIVPVTVPS RRGDVVVDTD EHPRDDVSLE SLAALRPVRL
RIDPESTVTA GNASGQNDGA AACLVTTPER AEQLGLRPLA RLVTWAAAGV EPHRMGIGPV
PSTEAALARA GLTLADMDLI ELNEAFAAQA LACTTVWGLG ESDFDRVNVN GSGISLGHPV
GATGVRILTT MLRELDRREG RLALETMCIG GGQGLTAVFE RTP
//
