ID   A0A417XVD6_9ACTN        Unreviewed;       713 AA.
AC   A0A417XVD6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=D0Z08_25330 {ECO:0000313|EMBL:RHW24240.1};
OS   Nocardioides immobilis.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=2049295 {ECO:0000313|EMBL:RHW24240.1, ECO:0000313|Proteomes:UP000283644};
RN   [1] {ECO:0000313|EMBL:RHW24240.1, ECO:0000313|Proteomes:UP000283644}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCTCC AB 2017083 {ECO:0000313|EMBL:RHW24240.1,
RC   ECO:0000313|Proteomes:UP000283644};
RA   Li C., Wang G.;
RT   "Genome sequencing of Nocardioides immobilis CCTCC AB 2017083 for
RT   comparison to Nocardioides silvaticus.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHW24240.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; QXGH01000034; RHW24240.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A417XVD6; -.
DR   Proteomes; UP000283644; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02120; PA_subtilisin_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR045051; SBT.
DR   PANTHER; PTHR10795; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN; 1.
DR   PANTHER; PTHR10795:SF468; SUBTILISIN-LIKE PROTEASE SBT3.18; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000283644};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..39
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           40..713
FT                   /note="Peptidase S8/S53 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019165301"
FT   DOMAIN          87..129
FT                   /note="Inhibitor I9"
FT                   /evidence="ECO:0000259|Pfam:PF05922"
FT   DOMAIN          152..580
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   DOMAIN          408..481
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   ACT_SITE        161
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        235
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        547
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   713 AA;  73469 MW;  4252D67E5E245A09 CRC64;
     MDRSGAVRAG RHRRRGRMRA AAIAAIVAAS TLVAVPSHAE DDDSTSLHLV TLRGPGTAGR
     QGAAAPDVVA QRMLALQADL LDDIGAGDPV YQWTTALNGF AVELTEAQHE ALVGDDRVAL
     VEENAVRPLA RVASAPAGSA TRPDRRADRT GGAGTVIGFV DTGIDPASAA FSEVAALGRT
     PRRFAGSCTD APDDGGWAET DCSAKVVGAQ FYVDGFGADA LRSASALSPR DTDGHGTASA
     SIAAGTSDVA VRSGQHRLGR FSGVAPRARI AVYKACWSAP DPDDDGCATA DLVAAIDRAT
     SDRVDVLNLS VGGPSGTIDT VERALLGATE AGIVVTAAAG NSGSAAYAAH PSPWVITVGA
     SMSARRVGAV VAANGPRLEG AMAATAPVRP APLVLGEDAA APGVSRADAA ICAPGSLDAR
     KVHEAVVLCE RGDVARVEKS MTVRLADGAG MVLVNTAAGS TDADLHAVPT VHLSARDGRA
     LRAWASDRRR PEVRLVSVGR ERAPLRVARF SSGGDPTWSV IKPDLVAPGT GVLAATTDGW
     DVVSGTSTAT AHVSGVAALL LSHRRNTPAE VRSALLTSTT PIGRQSGLRG GTGQVRISRV
     PPIAYLVDPR HYRGWLVGRR ADLDLPQALM RTGRLVVRRT ITNTGPRPLW LTTHLVGFDS
     PVHITPSAGL VRPGRTMTFT ISLPAAPRAT DKGTVAWNSA HGDETRLAVV ITR
//