ID A0A417XXR7_9ACTN Unreviewed; 1190 AA.
AC A0A417XXR7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=D0Z08_20960 {ECO:0000313|EMBL:RHW25166.1};
OS Nocardioides immobilis.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=2049295 {ECO:0000313|EMBL:RHW25166.1, ECO:0000313|Proteomes:UP000283644};
RN [1] {ECO:0000313|EMBL:RHW25166.1, ECO:0000313|Proteomes:UP000283644}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC AB 2017083 {ECO:0000313|EMBL:RHW25166.1,
RC ECO:0000313|Proteomes:UP000283644};
RA Li C., Wang G.;
RT "Genome sequencing of Nocardioides immobilis CCTCC AB 2017083 for
RT comparison to Nocardioides silvaticus.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHW25166.1}.
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DR EMBL; QXGH01000026; RHW25166.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A417XXR7; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000283644; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:RHW25166.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000283644};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RHW25166.1}.
FT DOMAIN 8..75
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 680..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1190 AA; 131462 MW; 41226695B54BBD01 CRC64;
MAAPGDFVHL HVHTEYSMLD GASLLDGLFT RVSDLGMPAI AMTDHGNLHG AYDFYSKARK
HGVKPIIGIE AYVTPGTDRS ERRRVRWGKG NTAEEGGDDV SGGGAYTHMT MWAETTEGMH
NLFRLSSKSS LEGYFYKPRM DKELLQTYSK GLIVSTGCPS GAIQTRLRLG QWDEAVREAG
ELQDIYGRDS VFLELMDHGI DIEKRVRDDL LKLGKQLGIP PIATNDSHYN NPEDASAHEA
LLCVQSGSRM SEPPYSQGGR RFAFEGTGYY IKSAAEMREL WGDHNDLREA CDNTLLIAER
CDVEFTESTG GYMARADVPA GETEESWFVK EVWRGIESRY PGDRLTPEVK QRVDMELGVI
ASKGYCGYYL VVADFIQWAK DNGIRVGPGR GSGAGSIAAY ALRITDLCPL EHGLIFERFL
NPERPSMPDF DIDFDERRRT EVIQYVSDKY GSDRVAYIAT FGRLKAKAAI KDAARVLDYG
FAVSDRITKA LPPDIMGKGV PLKEIFNADH KRYGDGAEFR ALYENENDVR TIYQTALGLE
GQIRNWGVHA AGVIMSSEPL IDIVPIMARP QDGAIITQLD YPMCEALGLV KMDFLGLRNL
TVLDDALDNI RANRGEEVVL EDLPFDDPAT YELLSAGDTL GVFQLDGGPM RALLRSMRPD
KFADISAVGA LYRPGPMGAD SHNKYARRKN GREPIDPIHP ELEKPLETVL GETYGLIVYQ
EQVMEIAQVL AGFTLGQADN LRRAMGKKKK EELDKQYAGF QSGMLERGYS QASITALWEI
LLPFSDYAFN KAHSAAYGVV SYWTAYLKAN YTAEYMAALL TSVKDDKDKM AIYLGECRRL
KIQVLPPDVN ESAKNFTPVG TDIRFGMTAI RNVGANVVEQ IVGARESKGR YESFNDFLDK
VPALVCNKRV IESLIKAGAF DDLKHRRRAL VAIHETAVDQ YVDIKRNEAI GQDSLFAGLD
DLDGGDFGVS VTIPDLDEWD KTTLLGHERD MLGLYVSDHP LLGLEHVLAG SADCTIGELM
TDEERPDQAT VTVSGLVTSV QRKITKKGDP WAMVTLEDLE GAIDVLLFPS AYQLASPHLV
PDAIITVKGR LSRSKEQPEL HGQEVSVPDL ETGTDGPVVI SLPATRCTAP VIAQLKEVLG
THPGLTEVRL RLLTREATKL MRLDDRLRVA PSPALFADLK QLLGPGCLAG
//
