ID A0A417Y8R6_9ACTN Unreviewed; 756 AA.
AC A0A417Y8R6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=HAD-IB family hydrolase {ECO:0000313|EMBL:RHW29099.1};
GN ORFNames=D0Z08_00495 {ECO:0000313|EMBL:RHW29099.1};
OS Nocardioides immobilis.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=2049295 {ECO:0000313|EMBL:RHW29099.1, ECO:0000313|Proteomes:UP000283644};
RN [1] {ECO:0000313|EMBL:RHW29099.1, ECO:0000313|Proteomes:UP000283644}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC AB 2017083 {ECO:0000313|EMBL:RHW29099.1,
RC ECO:0000313|Proteomes:UP000283644};
RA Li C., Wang G.;
RT "Genome sequencing of Nocardioides immobilis CCTCC AB 2017083 for
RT comparison to Nocardioides silvaticus.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the fatty acyl-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00005928}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHW29099.1}.
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DR EMBL; QXGH01000003; RHW29099.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A417Y8R6; -.
DR OrthoDB; 25607at2; -.
DR Proteomes; UP000283644; Unassembled WGS sequence.
DR GO; GO:0080019; F:alcohol-forming very long-chain fatty acyl-CoA reductase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09071; FAR_C; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.20.1440.100; SG protein - dephosphorylation function; 1.
DR InterPro; IPR026055; FAR.
DR InterPro; IPR033640; FAR_C.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006385; HAD_hydro_SerB1.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01488; HAD-SF-IB; 1.
DR NCBIfam; TIGR01490; HAD-SF-IB-hyp1; 1.
DR PANTHER; PTHR11011:SF45; FATTY ACYL-COA REDUCTASE; 1.
DR PANTHER; PTHR11011; MALE STERILITY PROTEIN 2-RELATED; 1.
DR Pfam; PF12710; HAD; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF03015; Sterile; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:RHW29099.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000283644}.
FT DOMAIN 17..324
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT DOMAIN 425..491
FT /note="Fatty acyl-CoA reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03015"
SQ SEQUENCE 756 AA; 82859 MW; 39F6FE94E897E32A CRC64;
MADRSVGARL AGQRVLLTGV TGFVGQALLQ LLLAEVPEIR LVVLVRAKGS ESGEDRFRQL
LGREIFTGIE GDADSLLGDR LTVVEGDLSD VPPLPGDLDA VVHCAGDVSF DPPVDEGFRN
NVVGTRALLE RVRQIGDHVH YVHVSTAYVA GRRRGFVPEA PVDHSVDVEA ELEWGLAQRQ
AVEHRSRSAD VLAGIRAKAE RQHSRAGSLS VATATEEKRK EWVRQELVRI GGERARSLGW
TDCYTFTKAL GERVVEEHAA NAPTSIVRPS IIESALAKPH PGWIEGFKMA EPLILAYGRG
ELPEFPSAPD TIVDIVPVDH VVAAVAAVLA APPRAGAPAY FHVATGARNP LSFGVLYDAV
RSYFDAHPFE LGDRGAARLP EWRFPGAPAV ERLLVTSERA HRVADHVIAR APRSDRVREL
ARKLDQQGRR LQFLRRYLDI YREYAVAELG FDDANTAALY DGLEARDRAV FAFDPRVIDW
PHYLAEVHCP AVTAPLRQYD EVRKARGRRS GAPRPVAATA QPHAAAFFDM DGTLLSSNVI
ETYLWLRLQE LDGHARFAEL TRIARRVPGL VRAERRDRGA FLRSVYKEYA GARLVDLDAI
ADEVLSGHVL ARLAPAAVRR VREHRAAGQP TVLVTGAIRP LTRPLAPLFD HIEAAELAVD
DRGVCTGFLA ASPLVGESRA AWMRQWAGEH DVDLAASYGY ADSHSDLPML EAVGNPVVVC
PDVALFRHAR KNRWPTVAWA SPGATGRTLN PAGDRR
//
