ID A0A418UR40_9ACTO Unreviewed; 2720 AA.
AC A0A418UR40;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:RJF40977.1};
GN ORFNames=D4740_10655 {ECO:0000313|EMBL:RJF40977.1};
OS Actinomyces sp. 2119.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=2321393 {ECO:0000313|EMBL:RJF40977.1, ECO:0000313|Proteomes:UP000284680};
RN [1] {ECO:0000313|EMBL:RJF40977.1, ECO:0000313|Proteomes:UP000284680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2119 {ECO:0000313|EMBL:RJF40977.1,
RC ECO:0000313|Proteomes:UP000284680};
RA Li J.;
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RJF40977.1}.
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DR EMBL; QYRR01000008; RJF40977.1; -; Genomic_DNA.
DR Proteomes; UP000284680; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 5.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000284680}.
FT DOMAIN 1143..1220
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2363..2438
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1425..1462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1500..1519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1446..1462
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2720 AA; 287494 MW; 18C4D90FFA4F83D4 CRC64;
MPAEQGPGRS SGTGRPEHDA RTGRTGGEVN EGTELTPAQQ GIWLSQHVLA DESVYGVAEV
TRIEGPLDTG AWLAAADRVL HDIPALRTRL VVKGDPGTAS PGRLGSPVGS LDDAASRPTV
PVGAVGEVDG RQAPAAGEGL PRVVLDAVPV RAGLVDLRQD PRGGQEAARQ WVLQHLGEPI
DLEQGVVSRA CLLLTGQDSA QWFLRVHHLA LDGYGFALVG RTLAREYSSR LSSQGAGSPA
APARGAAAVG TAPGAEADRS TGSTAGADPE AVEAYLEAVV QQAAYARSPQ AKEDRAFWRE
QAPDAPAVSM APGGDPSKAA YHPVEAPGPF AGADPTVLVA ALAVLAGVVH RRDEAVVGVH
VMNRTSQTLL RTPCHTQNVL PVRVDLDPDQ SVGQLLTQVS QAWQRCRDHQ RYRHEDIRAD
RGLAVSEALC DVAVNIVPFG GARRYGRARG RSEAVWEGPA EGLVLDVRPG QPDAPMGLAA
PAGSLSESVL AGYARVLETL VSRLSRAAHG TGTPEGAGAE MAGDTHERLR DLVLSPQVPY
VTGSPHPPDL QALPPEPEEV ASLPAAGQGR SATDPVWAVG ALDRARLATS SRLRPPGSSQ
EHLCAPDRLL TYEETASWAH RLTRLLRELG VGAGDRVLLY LPRTSWMVLA PPAVLEAGAA
FVPCDPQWPA RRLSQVVEDV EPAVVVTTSV LGQGPALRQA LSQAGGAGTR APQTLVLDAD
SVRAQMEALP AGPVAPGELD RPVRGEDAAY ILFTSGSTGR PKGVVVEHRN LSSYARAFDL
LYVDRELVAA GTTGWSGQVE REGQPGSTSG AGTTRESVVL DYSHEYSPAF DSALSPLVAF
LHGHRLHVPT EEQLGDPVAH ARFLQDHAVD VIDLSPAVLE QLLEVGLPVG RDREGRGHAV
TSLFIGGDTC SVSLWERLRQ ETRRGVFAAN GYGPTENTVE ATVAWVADHP EPSIGRSLPG
QEARVLDHLG RALPPGVTGE LYLCGSSVAR GYLRDDDLTR SRFVTAAGGS RCYRTGDLVR
READGALTFM GRADSQVSLR GVRIEVAEVE AALVTQPGIR QAVVTVRDDG DGARLVGYVV
PTQEQAPLDT AGVLDHLRGL LPPSFVPTTL VCLEALPLTE RGKVDRSRLP APGREVGAGL
SWEQMDPDQQ VVASVYAEVL DVPAHTLRSH TDLFSMGGHS LTAARVLGRL TQAGYQGLHL
RDFFRDASVE QVARLLGGTG PRPASSPGVG TGAEASGGTG AQAAGEAVGG AGSPGAPALP
VPASPAAGGR PLMTAAQRRL WFLEQEQGPS PVYAIPLVLD VAGHLDIRAL EAAVVDTVLT
YTALRTSYPA GEDGLPTVAT WQEAAVRQAV RLVVVDRDPH DPDLVSSLDT TIDVTAQPPV
RAYLAQDADR QRLVLVIHHV AADGWSLRPV VDTLAAAYRA RVQDLDRRNS PDPGQDAARR
ASGPGPRPAS SPPASVSFPR VSPPTPTPLP LVAVPPAPLP APAPEALSWW TERLRGLPEE
IPLPLDRPRP RQRDHRGGQV RVSLGAERSA AVEGLARAHQ ASPFMVLHSV LAGLLTRCGA
GYDVPIGTIS SGRTDARREQ EVGFLANTVV TRTSTEGNPS FAELLARVRE DTLTMLDHAE
VPFDAVVGAV NPRRDSSRHP LFQVMLVAQD TGGLSFDAGA GAPQVSVGVE GTGTSKFDLT
WEVTMGEGIC VRLEYATDVI DSATAQALTR WFLRLLDQML EDPHSRLWDR VLEEEAREQA
LQEATRMLGA RTAMPEATSP ALRRASLGQA LEAAMAQWAE REALTVPDEP GARGAGVPDA
PGAQRLTYAA LERVSARVRD VLLEAGAGPG RRVALLLRRG RLQVEMIVAV LRTGAAYVPL
DPQYPEARLA AALEDCQPVV LVHDLPDDAE GSPLPPGLRS ALGSQAVVLS ARDLEGGCSG
LPGQAPLLGR SPGQVAPPSA TCADDPAYVI FTSGSTGRPK GVEVTQDNVL RLLRSTEHRL
GLGAADVWTF FHSYAFDFSV WEVLGCLLTG GRLVVVPYEV SRSPEEMLAL LEAEEVTVLS
QTPSAFAQLA AADAQRDEAV AQEAGLGQVS QSGLGLRVVV LGGEEMDLDV VRRWFRRHPP
GSPRVVNMYG ITETTVHVTY LEVDEATTGN SPIGRPLEDL AVYLLDEGGH PVPAGVVGEI
HVGGAGVASG YVNQPGLSDE RFLPDPFALA VLEGAGHDGG VGGLLGAPRS AEALAAPAEA
AGPGSSGWAR QGRMYRSGDL AVRTRQGDLE FTGRADRQVQ LRGFRVELGE VEARAREVEG
VRLAYARVVQ VRQGDERLVL YLTGPDPTTA DPALLRRQVA RRLPGQMAPA AVVVLDRLAL
TVNGKRDDAA LPVPRLPRSQ GRAPATRTER LVCEHVARVL GIEGCSADDS FFDLGGHSML
AVSLVAALRK ATGRPLRVGT VMTHPTPALL AAHLDEHDPT RPGDTDLGVL LPLRPPDNRG
PGSGQGPGTD LGGVFCVHPA GGLSWCYAGL PRHLDGLPVW GLQARGVLEP GSQPTSLEEM
ARDYVTQVLQ VQPSGPYHLV GWSLGGMVAH VMAVLLQEAG HQVGVLALMD AYPSEAASGA
MEPPLADALS ALLAMAGIDD DVLAGHEEDL AAVVRALEER SSPMAGLERG VLEALVTTYR
NTTRILREYQ HRAYRGRALF LRAARGGIGP EHDPGEWEPY VTGGLQVVDV DCNHREMTQP
GALGVVGPVL DRAIRSAVSP
//
