ID A0A418WVP0_9BURK Unreviewed; 321 AA.
AC A0A418WVP0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:RJF96659.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:RJF96659.1};
GN ORFNames=D3870_19770 {ECO:0000313|EMBL:RJF96659.1};
OS Noviherbaspirillum cavernae.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Noviherbaspirillum.
OX NCBI_TaxID=2320862 {ECO:0000313|EMBL:RJF96659.1, ECO:0000313|Proteomes:UP000285190};
RN [1] {ECO:0000313|EMBL:RJF96659.1, ECO:0000313|Proteomes:UP000285190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K2R10-39 {ECO:0000313|EMBL:RJF96659.1,
RC ECO:0000313|Proteomes:UP000285190};
RA Zhu H.;
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RJF96659.1}.
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DR EMBL; QYUN01000003; RJF96659.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A418WVP0; -.
DR OrthoDB; 9777604at2; -.
DR Proteomes; UP000285190; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006398; Tartro_sem_red.
DR NCBIfam; TIGR01505; tartro_sem_red; 1.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:RJF96659.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000285190}.
FT DOMAIN 29..187
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 190..309
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 196
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 321 AA; 33645 MW; CE2CF746734A42A1 CRC64;
MNRLNQTNRA GKDASLHRSI FTVENNMAKV GFIGLGIMGA PMAANLQKGG HKLYLHDIRN
PPAELNERGA TICTSAEAVA NRSEIVIVMV PDTPQVEEVL FGEKGVAKGL AAGKIVVDMS
SISPIATKNF AKKINALGCP YLDAPVSGGE VGAKAASLTI MVGGPEEAFN TVKPLFELMG
KNITLVGGNG DGQTTKVANQ IIVALNIQAV AEALLFASKA GADPARVREA LMGGFAASRI
LEVHGERMVK RTFNPGFRIE LHQKDLNLAL QGAKSLGVSL PNTAAAQELM NACAANGISG
LDHSALCRAI EMMSNHQIAE A
//
