ID A0A419HIG3_9PSEU Unreviewed; 2572 AA.
AC A0A419HIG3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:RJQ75466.1};
DE Flags: Fragment;
GN ORFNames=D5S17_20715 {ECO:0000313|EMBL:RJQ75466.1};
OS Pseudonocardiaceae bacterium YIM PH 21723.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae.
OX NCBI_TaxID=2340915 {ECO:0000313|EMBL:RJQ75466.1, ECO:0000313|Proteomes:UP000285726};
RN [1] {ECO:0000313|Proteomes:UP000285726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM PH 21723 {ECO:0000313|Proteomes:UP000285726};
RA Miao C.;
RT "YIM PH21274 draft genome.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RJQ75466.1}.
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DR EMBL; QZFT01000046; RJQ75466.1; -; Genomic_DNA.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000285726; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000285726}.
FT DOMAIN 928..1002
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2379..2453
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2548..2572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2548..2562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2572
FT /evidence="ECO:0000313|EMBL:RJQ75466.1"
SQ SEQUENCE 2572 AA; 277691 MW; 1F740CD723F35E27 CRC64;
MNTHPALLEL TGAQLGIWNA QRLEPDSLYY VVGDVFEIAG EVDERLLAQA IRSTTEEAES
LRLRVVDTPD GPRQWIDREP VPLPVIVDLR AEADPRGAAE RLVAAERERV ATQARGMTER
DLFSHTVIRV SEKETWYTQL GHHLVFDGYT AAMLGRRTAE HYGALVRGEQ PGPSPFGSFA
EVVAGDLAYR VSERAETDRA YWRERFSPLP EVDSGSGSGT PERTITVRAV LGAAELDRLK
EVAARTKGTW AEVLIACYAA YLHRVLGSTD VVFAMPLMCR AGVELRTPAM AVNVLPLRVP
VRGGDTLDVL CKRIALVMRE MRKHQRYRGE DLPRDVPGAG ALLHGRGINL KNFDLALDFA
GSVGVMRNVA GGPPEDMGLS VLPTADGGLL LGFEVDAATH DQSGVDRMLE SLLGLIHTLT
EPSQPPVGQV RLAGAEVLPE WSTPSVVPVS GLLDDVGTLV CGASRSGGPE LAARVRRVAD
GLRARGIGPD DVVALALPRS IDLVVGLLAV LEAGAAFQPL DLEHPIGRLR DLVADTGAVL
ALSTEDLLGI PWVTVSEVGD VRERNEPEHR QLRDHGSSPE NLAYVIHTSG STGRPKGVLV
RRGGLLSLLS HHRATTIPET AQGRELRVAH TYSFAFDSAI DQLGWLLAGH ELHLYDADTA
RDADELLAAI RRDRIDVVDT TPSLAAPLLD AGLGDLRLLV LGGEATPPAL WTRVVQAGIP
ARNMYGPTEY TVDVTTAVVD GEIPTIGFPV SGTRIYLLDG ALQPVAAGEA GELYVSGPQL
ARGYLGQPGL TAERFVADPY GPAGARMYRT GDVARWVPGR GLEFTGRRDG QVKIRGHRVE
LGEVDAALGA LPGVRAAAAA VHGNRLVGYV VPDGAISPDS VRDELAQRVP DHLVPAVVVL
LDALPVTTNG KLDRAALPAP RMSGTGRQPS TERERVLVSV IAEATGVDDV GIDDDFFSLG
GDSIIAIAVS ARLRAHGMHL RPRDLLERRS LASLAAAITG TVAARQEHDP VGPVPAPPIV
RGLLDPNRYV PVIAGYAQWT APHVLDLDIE TLRRGVDALV EHHDALRLRW FADGLEILPR
GTARAVVTEA EVLTESVESF AQRVAAGLDP DFGPMLRVVL LHTPDGDRVV IVAHHLVIDG
VSWRVLLPDL QAACAGEQLQ PVGTSWRHHA LTLAEQGRTG ARRSELDHWR STVDEFRLGD
RALDPRRDTM ATAKVTVLTA TARQSEAVLG TLPAAYRMGV DEVLLAAFAL TVQESVTVRL
EGHGRDLADA DLSRTIGWFT SEYPVRVPFD HDPGRVLRGA KQAKRSTPDH GLGHGVLRYL
DPSTQDEFAG QPDVLINHLG RFAPLPGAWW LPEGDPFAVT EPAAKALEQV LALNSFVHED
GTLAIEWTAA GEILSEQAVR ELQTAFSAAL ETLAEHAESV GDFGGLTPSD LPLVNLDQDT
IDSLGRIEDV LPATALQAGL AFHSLVRGED EADVYVVQAV THLQGHIDAD RMREAARELL
RRNPALRLHL HTTAGGEVVQ VVPADVQLEF RLVERGADSA ENAQDAFSAE SASDLTRSFN
PDRPPLIRFL LGADRLAITV HHALLDGWSM PIVGRTLFAI YAELGGGERA TTAPPLSEYH
RWLATRDRAT GLQAWREALS GVDEGTRLAR ESTTIERPHR VTVPLGAEFS DQLRRFARSR
GVTASTVLQT GWGVLLGRLT GRQDVVFGCP VSGRPAEVDG VESMIGQLGN TIPVRVHYGL
GDTAAQVLDR VHADAVTLAE HHHIGLPDIQ RQAGIGELFD TMFVMENFPL SSRDHIPIAP
GLELTGVDIT DATHYALTVI VLPGDEITIG LDYQPTEFDE PTIQAYGRWL RTLLQQIVTA
PDRPMALLSN LDGDERAAIL RMSDGPVPRR ERGGTLTEFA RWVQATPDAE AVVCRDRSLS
YVELDRAANR LANALIEHGV RPQDPVAVML PRDVEMVVAL LAVFKAGAVY VPMDPDYPQD
RLAYMAGDIK PAAVIGHHRF GDYPLVRPET DAPETDPVQA RAQITDDSLA YVIYTSGTTG
KPKGVGIPHR GVPSLVALQE DVVGIGEQER YLHFASTSFD VAFWQFMLPL LSGGASIIAP
EEVRVPGDEL LDYIAEHRVT GINLLPSFLA AMPDDATIPD DIFMVVGAER LDPELAHRWG
RGRRALFNAY GPTEVTINST IWVYDENDPG PLPIGLPDPE IRAYVLDAGL NPVGVGVTGE
LYLAGPKLAR GYINRPDLTA ERFVADPYGE PGERMYRTGD RVQWRADGQI VFLGRADHQV
KVRGFRIELS EIETVLTQHP QVRACAVIVR DGRLVGYVIP VDDVRLDLDD VRAHLAAELP
DHMVPAAFVE LTALPLTPGG KLDRAALPAP EFRATEARAA SNAAEELLLD VFREVLGRVD
VQLDDAFLDI GGDSIVSLRL VSRARRAGLE LTARDVFEGG TVAGIAARAR LAVQAVEEPG
VGDAPLTPVM RALLERGGNV DGFCQWVEIS VPAGGTPRRW QAAIDALLTR HDALRAHLAG
DVLRIPAPGS VTAAQVFTQV KAKMGAEVGD VRGKERDHRA GSAQRGAGGG RA
//
