ID A0A419PCS7_CLOSI Unreviewed; 514 AA.
AC A0A419PCS7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Cathepsin L {ECO:0000313|EMBL:KAG5451856.1};
GN ORFNames=CSKR_111233 {ECO:0000313|EMBL:KAG5451856.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:KAG5451856.1, ECO:0000313|Proteomes:UP000286415};
RN [1] {ECO:0000313|EMBL:KAG5451856.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Cs-k2 {ECO:0000313|EMBL:KAG5451856.1};
RX PubMed=29454982;
RA Wang D., Korhonen P.K., Gasser R.B., Young N.D.;
RT "Improved genomic resources and new bioinformatic workflow for the
RT carcinogenic parasite Clonorchis sinensis: Biotechnological implications.";
RL Biotechnol. Adv. 36:894-904(2018).
RN [2] {ECO:0000313|EMBL:KAG5451856.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Cs-k2 {ECO:0000313|EMBL:KAG5451856.1};
RX PubMed=33677057;
RA Young N.D., Stroehlein A.J., Kinkar L., Wang T., Sohn W.M., Chang B.C.H.,
RA Kaur P., Weisz D., Dudchenko O., Aiden E.L., Korhonen P.K., Gasser R.B.;
RT "High-quality reference genome for Clonorchis sinensis.";
RL Genomics 0:0-0(2021).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG5451856.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NIRI02000042; KAG5451856.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A419PCS7; -.
DR STRING; 79923.A0A419PCS7; -.
DR InParanoid; A0A419PCS7; -.
DR Proteomes; UP000286415; Chromosome 1.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 1.10.287.2250; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR013201; Prot_inhib_I29.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 4: Predicted;
FT DOMAIN 63..119
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 146..353
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 514 AA; 59609 MW; 83A53BB49938EF34 CRC64;
MSYDFVHIPL ILALFVYGIV SELYEWDILI NANTKMGLIL EGNASRCMES LNEHLNYTMH
IAWKQFKHEF NRNYSNSKEV AKRMNLFCNS FLIVRKHNMA YNKDKELYNL GINEFSDEVS
DCIRSIFRLL QTSEESSHTC ISDLQLPDTT EFASTYRMIS AEPLKTYRLE SVWCSHTSQT
SGGLWMLLGF RQSWVDRVAL FFAQAISLHT VTATGCHGGY LPWGYRYINQ TGGLERELNY
PYVSGGTGQP NPKCLFDKRK MAAKIVGLNA VPFYNEKAIT QAVGFFGLVA ILINASPETF
RRYRGENLNN ILYSSRSGSW VAVISIFQWN YYIRLHNSDT NSTRSTGCPV RFYLRRQRNH
LAVTSDFLEH KHKLSEYSYN RLPVYRRLTE YELGTCRALL KYGTPSCEVR LFVADEFGKI
LATQDVYNYR RNCRPALLIC RYALYTLLMT HGMSSARMPM YAFVESEQFT PMRKLNYLFR
LSLPFSPVEM DECTPASLVR SAVRYDRRRF HVVS
//
