ID A0A419V4D7_9BACL Unreviewed; 756 AA.
AC A0A419V4D7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=ATL39_1647 {ECO:0000313|EMBL:RKD73354.1};
OS Sinobaca qinghaiensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Sporolactobacillaceae; Sinobaca.
OX NCBI_TaxID=342944 {ECO:0000313|EMBL:RKD73354.1, ECO:0000313|Proteomes:UP000285120};
RN [1] {ECO:0000313|EMBL:RKD73354.1, ECO:0000313|Proteomes:UP000285120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17008 {ECO:0000313|EMBL:RKD73354.1,
RC ECO:0000313|Proteomes:UP000285120};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKD73354.1}.
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DR EMBL; RAPK01000008; RKD73354.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A419V4D7; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000285120; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR InterPro; IPR025916; YdjO.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR Pfam; PF14169; YdjO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000285120}.
FT DOMAIN 51..325
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 326..599
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 72..79
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 756 AA; 86562 MW; D4477332A91DD32D CRC64;
MENTSFEKTP FGIISPVVPE ADLAREESDA EQTDGGEEDY FYFRALKEKG ISLNQSQTKA
VRHGEGPFLA LAGAGSGKTS VLVCRTGYLL AVRKIPAAHI LLVTFTKKAA EEMKERIAAL
PGISAQAVRQ LQVRTFHSFF LQLLRGQGYD QKMITSERFK HIIIKKKLKE AGFDGKYQPE
TLLSLYSSYR MNNLSLAEMP AENPMEIEQK GVFRRYEAWK KEEHQLDFDD ILCHAYELLC
ESETLLRKMQ ERFKYIMVDE FQDTNPLQYE MMKMLSASHK NLFVAGDDDQ TIYSFNGAQS
EIILEFDKEF PTAEMATLDV NYRSTSPITG LGNEVIRHNT NRREKTLKST VMSQTYPLYF
RAETTDEEAK LAAADILHKV QNDGRSFADF AVLHRTASVS RAMFEQLTLH QIPFLSFTTV
DQMFYNQWPI KAVMDHLRLA LNPYYNEALP EVLPTLFINR EKGMLHIKRL EAVGEQAEPL
ELLQSLGGLR TFQVGKLQER ERLLKQLKPM KPKQAIKKMR ETFYDTYLEA NEAQAETMHK
EGVKETLDEL ESSAGRFDSV LAFVSFVDDM VEMYKGMQKK TQAAKTDAVS LMTIHRAKGL
EFPVVYLIGA SETILPHSSA VKASGSKDFI KKSNESEEKA LEEERRLAYV AITRAKEELY
IGSPAQYRGK AVEVSRFFLE AFPHATQKRR QPMEQQPEER KIVKAWLCTN EDCIVWVKIQ
TQEDDTLQEK TCPICKSKME KGEKEVIIAQ RRNGRR
//
