ID A0A420E901_9ALTE Unreviewed; 1159 AA.
AC A0A420E901;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=DBZ36_13995 {ECO:0000313|EMBL:RKF15936.1};
OS Alginatibacterium sediminis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Alginatibacterium.
OX NCBI_TaxID=2164068 {ECO:0000313|EMBL:RKF15936.1, ECO:0000313|Proteomes:UP000286482};
RN [1] {ECO:0000313|EMBL:RKF15936.1, ECO:0000313|Proteomes:UP000286482}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALS 81 {ECO:0000313|EMBL:RKF15936.1,
RC ECO:0000313|Proteomes:UP000286482};
RA Wang Z.;
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKF15936.1}.
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DR EMBL; RAQO01000008; RKF15936.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A420E901; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000286482; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR048472; DNA_pol_IIIA_C.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR049821; PolIIIA_DnaE1_PHP.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF20914; DNA_pol_IIIA_C; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF160975; AF1531-like; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:RKF15936.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286482};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RKF15936.1}.
FT DOMAIN 9..76
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1159 AA; 130722 MW; 404E0AA700E83EB7 CRC64;
MTLNPPQFVH LRIHSDYSMV DGMNKVKPIV AHCQQLGMPA MAITDQCNFC GLVKYYGAAH
NAGIKPLVGA DFWVRSDSFG DELFRLVLLA KNNDGYQNIT RLISDAYLRG AIEDKPVIDL
DWLIKYNSGI IVLSGGREGD VGKALLRGKT EVAQECIEFY QRHFNHHFYL ELIRTGREDE
ERYIHLAVEV ALQFQLPVVA TNEVMFLKPQ DFEAHSVRVA IHDGFAMDDK RRPRRYSAQQ
YLRTEAEMLE LFSDIPVALQ NSVEIAKRCN VTIRLGEYFL PDFPTNGKSI EEFFCDVSRV
GLEERLEFLF PDPLVRAEKR PAYDERLEIE LGVINKMGFP GYFLIVMEFI QWSKDNNIPV
GPGRGSGAGS LVAYAQKITD LDPLEFDLLF ERFLNPERVS MPDFDVDFCM DRRDEVIEHV
AELYGRDAVS QIITFGTMAA KAVVRDVGRV QGQPFGFVDR ISKLIPGDPG MTLAKAFEVE
PRLQEIYDAD EEVQELINMA RTLEGVTRNA GKHAGGVVIS PTTITDFAPL YCDAEGNNPV
TQFDKNDVEY AGLVKFDFLG LRTLTIIQWA LDMLNPVLLS QGKDPIDIAS IPVDDPASFR
LLQKYQTTAV FQLESRGMKD LIKRLQPDCF EDMIALVALF RPGPLQSGMV DNFIERKHGR
EAVSYPDEKW QHDSLQEILE PTYGIILYQE QVMQIAQVLA GYTLGGADML RRAMGKKNAD
EMAKQRAIFK EGAINNNVDG ELAMKIFDLV EKFAGYGFNK SHSAAYALVS YQTLWLKTHF
PSYFMAAVMS ADMDNTDKIV TLVDECNSTN IPIIPPDVNS GEYKFSVNEQ QQIVYGIGAI
KGVGEGPVEA ILEAREAGPF IDLFDFCNRV DLKRINRRVL EKLIMAGALD QLGPHRAALM
ATLETAMKSA SQHAAASARG QEDLFGLIAS SDQESRPDFV TIDPWIDRVW LEGEKETLGL
YLTGHPINQY VKEFKSYTSS RLIDLRPSNK DTITVAGLVL SSRVMMTKRG SKMGILQIDD
RSARLDVMLF SEAFEKYQDL IEKDRILIIQ GQVSFDDFSG GLKMTAREIM DLGQARERWA
KRLVLNINED DTHEQYWQRF CEIIEPHRHG TCPVAIRYQG SKASAEYILA NDWRITPSEE
LLDGLSEMLG QANLALEFS
//
