ID A0A420HEM0_9PEZI Unreviewed; 921 AA.
AC A0A420HEM0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE SubName: Full=DNA mismatch repair protein msh-2 {ECO:0000313|EMBL:RKF55892.1};
GN ORFNames=GcM3_199039 {ECO:0000313|EMBL:RKF55892.1};
OS Golovinomyces cichoracearum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Golovinomyces.
OX NCBI_TaxID=62708 {ECO:0000313|EMBL:RKF55892.1, ECO:0000313|Proteomes:UP000283383};
RN [1] {ECO:0000313|EMBL:RKF55892.1, ECO:0000313|Proteomes:UP000283383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMSG3 {ECO:0000313|EMBL:RKF55892.1};
RX PubMed=30253736; DOI=10.1186/s12864-018-5069-z;
RA Wu Y., Ma X., Pan Z., Kale S.D., Song Y., King H., Zhang Q., Presley C.,
RA Deng X., Wei C.I., Xiao S.;
RT "Comparative genome analyses reveal sequence features reflecting distinct
RT modes of host-adaptation between dicot and monocot powdery mildew.";
RL BMC Genomics 19:705-705(2018).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKF55892.1}.
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DR EMBL; MCBQ01019995; RKF55892.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A420HEM0; -.
DR STRING; 62708.A0A420HEM0; -.
DR Proteomes; UP000283383; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000283383}.
FT DOMAIN 730..746
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 921 AA; 103852 MW; 521169EC2FADAF3E CRC64;
MSSRPELKID DEGGFIRFFR NLTSEPNGAV RIFDRGDYLT AHGEDASLIA RIVYKTTSVL
RYLGKDDATG LPSVTMTNTV FRNFLREVLL NLGRRVEIWT SQGRNSWVIS KKASPGNLQE
IEEEIGSYYN SAPILIAVKI SAKASEIRTV GVCFADTSVQ ELGVSEFLDN NLYSNLESLL
IQLGVKECLI QTENSDKEVE MKKLKSILDK CGISLSERPS SDFSIKDIEQ DLSRLVRDNN
FAGILPQTDL KLAMGSAAAL IKYLEVLHDP SNFGKFRIYQ HDLCQYMKLD ASALKALNLM
PGPRDGSKTM SLYGLLNQCK TPVGSRLLAQ WLKQPLMDKE EIETRQQLVE AFVEDSELRQ
TIQEEHMRSI PDLHRLSRKF QRKKAGLEDV VRLWQVVAAL PGFVNTLEGV MDDKYKDNLD
VAYTNKIKEY LNSLEKFQEM VEMTVDLDAA QNNEYVIKPE FDEKLQLIRK SLEKSRFNME
QEHKAAGKDL NQDIEKKLFL DNHKIHGWCL RLTRAEAGCI RNNKKYQECS TQKNGVYFTT
QKLQSLRREF DQLSENYNRT QSSLVNEVIN VAASYCPVIE LLAGVLAHMD VIISFAHCSV
HAPISYIRPK IHTRGTGNTI LKEARHPCLE MQDDIQFITN DVTLKRESSE FLIITGPNMG
GKSTYIRQIG VIALMAQVGC FVPCTEAELI IFDCILARVG ASDSQLKGVS TFMAEMLETA
NILKSATSES LIIIDELGRG TSTYDGFGLA WAISEYIVRE IGCFSMFATH FHELTALSEN
FPQVKNLHVV AHINTANEQK KAKREVTLLY KVSDGVCDQS FGIHVAELVR FPEKVVNMAR
RKADELENFT GKQDTAIALC SESDVETGSQ LLKEVLSQWK SDCEVQGANL GKEEKVQRLK
DLVQKNKQLL ANPFFKSVIA L
//
