ID A0A420HJF5_9PEZI Unreviewed; 1184 AA.
AC A0A420HJF5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=OnM2_073026 {ECO:0000313|EMBL:RKF57565.1};
OS Erysiphe neolycopersici.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Erysiphe.
OX NCBI_TaxID=212602 {ECO:0000313|EMBL:RKF57565.1, ECO:0000313|Proteomes:UP000286134};
RN [1] {ECO:0000313|EMBL:RKF57565.1, ECO:0000313|Proteomes:UP000286134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMSG2 {ECO:0000313|EMBL:RKF57565.1};
RX PubMed=30253736; DOI=10.1186/s12864-018-5069-z;
RA Wu Y., Ma X., Pan Z., Kale S.D., Song Y., King H., Zhang Q., Presley C.,
RA Deng X., Wei C.I., Xiao S.;
RT "Comparative genome analyses reveal sequence features reflecting distinct
RT modes of host-adaptation between dicot and monocot powdery mildew.";
RL BMC Genomics 19:705-705(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKF57565.1}.
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DR EMBL; MCFK01007332; RKF57565.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A420HJF5; -.
DR STRING; 212602.A0A420HJF5; -.
DR Proteomes; UP000286134; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000286134};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 39..105
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 716..836
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 894..1141
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 1184 AA; 134055 MW; EA2C3DDB7BE765AA CRC64;
MIYRPLRQSK SLAQMQMTPP VTPMGSFENI NELINNDTKF PNFLRATYPY NPSYAPADNA
VTLEFNEGDI ILIHTTHVNG WADGTILTNG ERGWLPTNYC KTYEPEPMRI LLLSFLNLWE
QVRYNLGRNV NRFPTQELMR CILAGVRYLL ERTECLTKDS ALIEENDKLR RIRRALLSDL
SSLVKYTNIL QEIPPSTNIK SDELQRSKLI CRDMMLNAFR LIRRGARFLD VWNDEVKTRP
NFCPESVLNR IAPVVEETKT PPSTPIDYLG ESASYYNSYG SLNKRKSNPC LNTGLGKSEP
YRKEIKTSID RISSGYFSPI YCSSGSTQND SCQSQQHSVT HGISSTVPVS QRQNFASERL
NSSHDTLLSF LGSLIGRLHS QSQPPAEFIS IVEQFVLAGQ ELLNVVKIIC DHDPQGTQLL
LLNRNIMQER IHQLVKDARE TISCTEDDEI TIVSPSQKTR LLMDSTTCVK AAGECVAKTK
FVLERIGDFE FESQNDDSKT QIDSTNELSS VYSQDQNEGW DLPEVVNNVK EPPTSSPPPI
PFTTPNYQKP LPEVPPKFPS LMEVDLSTFS QHSPLETESH ISLYGDSVES TSKANLPSIP
ISTDPTNLAN DLLPLARLST QDASSDISSI KNSISTTNER CNIMYLSSLR NSDTSMTSMN
STRATTPDQS LTVSNSQISY SELSLCSGHS ISMEDQEETE CKLLEKTFAH ELVFNREGGI
IGGSLSALVE RLTLNDSSPD TSFVSTFFLT FRLFVTSEAL ASKLIERSEY ASENSETYHL
VRMRIYNVFK IWLEFYWCRS TDYTAIGAIE LFATNKLHKN HPVAAQNLKE LLIKVSSFDT
LPQTASLLRK PSISVDKYLL TNTQTPNPIM SKNNFSFLRN WKLGEYNPTI LDFDPLELAR
QLTICGMRIF CSIRPEELLA SRLSKRSNPD APNVRAMAAF STDLSQFVWD SILQQEESKK
RANILKHWIK VAQKCLELNN YDCMLAIVCS INSSSISRLK KTWETVSQRR KDLFQSLLSI
ASNDHNCSTL RQRQSNHAPP CLPFIGIYLT DLGFADLGNA ATRPLPAMGN KEGQKVINFD
KYIRMAKIIS HIQRFQLPYR LHEVPELQDW FLTLFRQIRS SLNGADGSAY YYEKSKLLEP
RDSHASLRSP TEISFSSTYK EKFDIFGWVH KDRSSSIVQT LLNN
//
