ID A0A420Y9J7_9PEZI Unreviewed; 1688 AA.
AC A0A420Y9J7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 08-NOV-2023, entry version 15.
DE RecName: Full=Ras GTPase activating protein ira2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DL546_000918 {ECO:0000313|EMBL:RKU44545.1};
OS Coniochaeta pulveracea.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Coniochaetales; Coniochaetaceae; Coniochaeta.
OX NCBI_TaxID=177199 {ECO:0000313|EMBL:RKU44545.1, ECO:0000313|Proteomes:UP000275385};
RN [1] {ECO:0000313|EMBL:RKU44545.1, ECO:0000313|Proteomes:UP000275385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAB683 {ECO:0000313|EMBL:RKU44545.1,
RC ECO:0000313|Proteomes:UP000275385};
RA Borstlap C.J., De Witt R.N., Botha A., Volschenk H.;
RT "Draft genome of the lignicolous fungus Coniochaeta pulveracea.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKU44545.1}.
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DR EMBL; QVQW01000029; RKU44545.1; -; Genomic_DNA.
DR STRING; 177199.A0A420Y9J7; -.
DR Proteomes; UP000275385; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR CDD; cd21206; CH_IQGAP; 1.
DR CDD; cd05127; RasGAP_IQGAP_like; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 9.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 10.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000275385}.
FT DOMAIN 299..405
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1052..1268
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 819..846
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 19..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1688 AA; 193151 MW; 534B65C02622FDFA CRC64;
MSSNFRPSTL RHAETFDPSV YRQPSNASSS ASSGYSNSSG AYEFSSRIGT GASSPSSMYS
NSFGHKRGQS DFGRTLPTIP AVDNLLGKPT SDNLYNVARQ SLRPLPQAPS PVTTPPRTSI
HQRDRGQSFD TNKKGLREGH ARGQSLDISK LSLRNRNEEE QENRPRTPQT PPRPQAVRPN
SMLLTRSDSV SVGSLAVGHA HSPAPNHVHH TRNTSQLARP DLEKLGRSST SHLRTLSKFA
QSDSPDEVAL TAPTQEVVGL RGRRRLQRAD GNAPKKQYGW ESRNWMDKQR QFLQAYEYLC
HIGEAKEWIE DIIHRSLPPI VELEEALRDG VTLAEVVEAL NPDRRFRIFR HPKLQYRHSD
NIAIFFRYLD EVELPDLFRF ELIDLYEKKN IPKVIYCIHA LSWLLFRKGI VDFRIGNLVG
QLEFEHHELE AMQKGLDKLG ANMPSFGTMG ADFGEPATPE PEPEPEETEE ERIQRELAEN
EEVVMDFQAQ VRGAMVRMRL GDTMQQLWDA EPALVELQSV IRGGFSRQIF DYRLQMRRFA
VNLQSAARGF LARRRQGQRE MVMEAMEPDI LELQSIFRAQ QVRKQVREVR SHLDRANGPT
RDIQAAIRGF LARERVQDQQ HETKVAAGAV PELQSKIRGM LLRKRLEGEQ ISLERQAPAI
AGLQAAVRGM LTRNQVAYQL GTLDNFLPKW EALQAACRGN LARAKVKALE AELGEHLPQI
GRLQAAIRGS AVRREVSETL EALGEAESEV LNLQSATRGM LLRNRVAADY DALLEEEPGI
IDLQSRIRGC LYRQQQSDLL EELETAEGEV ITVQAAARAM LLRAQIAQLL EELDEQEESI
VEVQAAAKAF IVQARFEEKK RFFNENMQKV VKIQSLVRAK LQGDAYKNLT TGKNPPVGAV
KNFVHLLNDS DFDFNEEVEF ERMRKTVVQQ VRQNEMLEQY IDQLDIKIAL LVKNKITLDE
VVKHQHNFGG HAGNLLANSS IANANQFDLK ALNKGSRKKL ESYQQLFFTL QTQPQYLARL
FRKVREQGTA EKESKRIEHL MMGLFGYAQK RREEYYLLKL IGRSIKEEIE ASGTVQEYTR
GNFFWSKLLS NYSRSPRDRK YLRDLLGPLI RDNIIEDPAL DLESDPMQIY KSAINNEELR
TGRPSQRPLD IPREMAIKDP ETRELFIGHL QDLRYICDQF LVALEDLLPR MPYGLRFVCR
QMFEGLCQNF KREPQHVLLQ VVTNWLWRFY LQPAVTEPQN VGVVDKQLSP LEKRNMGEVA
KVLSQIASGR PFGGDNIYLN PLNAFVADSI ERLAHISHQL ISVPDAEATF DIDEFNDLYA
KNKPTLYIKM TDIFAIHNLV ADSLPFICPN RDDMLREIIQ DLGSAKNNES EMTAAGSSDI
QMFLTPKLHD MDDPEADIKA LFMETKRCIL YIIRVQTGTN LLEILVKPVS REDEHKWMML
LREDFADGSN TRGAYSDANM VDVSRMSYQQ LKRTALENIL RLEQMGRISK HNFYQDILNA
IALDIRTKSR RRVQRQRELE GVRLTLGNLH EKAKYLEQQR KSYDDYIEQA MKTLQNKKGK
KRFLLPFTKQ YNHQRELERS GRVPKFGSYK YSARALSEKG VLVGWQGVPE RDWNQINLTI
SCDEVGVFIL EGSRGHIQIP GASALVPIED LLQAQFEAHQ FMNLFEGNLR LNVNLLLHLL
YKKFYRTQ
//
