ID   A0A420YEI1_9PEZI        Unreviewed;       337 AA.
AC   A0A420YEI1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 11.
DE   SubName: Full=Methylglyoxal reductase (NADPH-dependent) gre2 {ECO:0000313|EMBL:RKU46332.1};
GN   Name=GRE2_3 {ECO:0000313|EMBL:RKU46332.1};
GN   ORFNames=DL546_008475 {ECO:0000313|EMBL:RKU46332.1};
OS   Coniochaeta pulveracea.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Coniochaetales; Coniochaetaceae; Coniochaeta.
OX   NCBI_TaxID=177199 {ECO:0000313|EMBL:RKU46332.1, ECO:0000313|Proteomes:UP000275385};
RN   [1] {ECO:0000313|EMBL:RKU46332.1, ECO:0000313|Proteomes:UP000275385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAB683 {ECO:0000313|EMBL:RKU46332.1,
RC   ECO:0000313|Proteomes:UP000275385};
RA   Borstlap C.J., De Witt R.N., Botha A., Volschenk H.;
RT   "Draft genome of the lignicolous fungus Coniochaeta pulveracea.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. Dihydroflavonol-4-reductase subfamily.
CC       {ECO:0000256|ARBA:ARBA00023445}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RKU46332.1}.
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DR   EMBL; QVQW01000015; RKU46332.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A420YEI1; -.
DR   STRING; 177199.A0A420YEI1; -.
DR   Proteomes; UP000275385; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd05227; AR_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10366:SF564; 3BETA_HSD DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000275385}.
FT   DOMAIN          4..259
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   337 AA;  37284 MW;  FEAF5F99810F7FFE CRC64;
     MAKVLLTGGN GFIASHILDI LLKRGYDVVT TVRSQDRGEK ILERYPHVPS EQLSYVVVSD
     IAQVGAMDQA VRSTPPFDAV IHTASPFTQK WDDPVKDILE PALKGTVGTL ESIKNHAPTV
     RRVIVLSSFA ALINYISPPK VYDETSWNPV TWDAAVSNPR LTYPGSKTLA EKAAWDFIQT
     RSPSFDLVTI NPPLVFGPTI HFVPGLDRLN TSNQRIRDLV QGTYRDTPLP PTGVYLWVDV
     RDVAEAHVRA LKTPEAGGHR FLLTAGYFSN KNLADVISTT HPELKDRLPR DAVDDTPADV
     YGFDNEKAKR VLGVTYRSLE ESVRVTVSSI LEIADRS
//