ID A0A420YM76_9PEZI Unreviewed; 829 AA.
AC A0A420YM76;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=GEF1 {ECO:0000313|EMBL:RKU49007.1};
GN ORFNames=DL546_009676 {ECO:0000313|EMBL:RKU49007.1};
OS Coniochaeta pulveracea.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Coniochaetales; Coniochaetaceae; Coniochaeta.
OX NCBI_TaxID=177199 {ECO:0000313|EMBL:RKU49007.1, ECO:0000313|Proteomes:UP000275385};
RN [1] {ECO:0000313|EMBL:RKU49007.1, ECO:0000313|Proteomes:UP000275385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAB683 {ECO:0000313|EMBL:RKU49007.1,
RC ECO:0000313|Proteomes:UP000275385};
RA Borstlap C.J., De Witt R.N., Botha A., Volschenk H.;
RT "Draft genome of the lignicolous fungus Coniochaeta pulveracea.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKU49007.1}.
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DR EMBL; QVQW01000003; RKU49007.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A420YM76; -.
DR STRING; 177199.A0A420YM76; -.
DR Proteomes; UP000275385; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711:SF9; ANION_PROTON EXCHANGE TRANSPORTER GEF1; 1.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000275385};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 110..131
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 176..200
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 212..238
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 250..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 278..302
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 314..331
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 352..371
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 391..412
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 446..464
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 519..543
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 549..569
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 603..665
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 710..766
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 829 AA; 92096 MW; B9BD0CA0A2F9C665 CRC64;
MNSRTASTSS SYFPQPIRRP SSITSRFSFV TTPAAERGEH NQHGLAGLQI EEEIAEIKRY
EDFTTIDWVQ DADREHLRRK AKQRRNAGLS DRVRFDWRHR LLESYDAAQG WIVVTIIGAA
IGMNAAFLNI ITEWLSDIKL GHCKTGFYLN ENFCCWGEDN GCADWQRWTG FEPINYVIYI
LFGTLFALTS ATLVKSYAPY AAGSGISEIK CIIAGFVMKG FLGFWTLLIK SIALPLAIGS
GLSVGKEGPS VHYAVCTGNV ISRLFDKYKR NASKTREILS ACAAAGVAVA FGSPIGGVLF
SLEEMSSYFP LKTMWRSYFC ALVATAVLAA MNPFRTGQLV MFQVRYDRSW HFFEVVFYII
LGIFGGLYGA FVMKWNLRAQ AFRKKYLTKY AILEATILAC ATAIVCYPNV FLRIDMTESM
EILFLECEGA EDYRGLCEAE HRWKNVLSLL LATVIRVFFV IISYGCKVPA GIFVPSMAIG
ASFGRTVGIL VQALHESYPQ SVFFASCEPD VPCITPGTYA FLGAAAALSG IMHITVSVVV
IMFELTGALT YILPTMIVVG VTKAVSELFG KGGIADRMIW FSGFPFLDNK EEHNFGVPVS
QAMTTDIVAI PTLGMTLQTI ERLLSQDKYQ GFPIVEDERS KVLVGYIGRT ELRYAVDRVK
RERSVSPLAN CTFGPSPSAT THHNVATPLT PTVTYDGADS STSIDFSRYV DTTPVTVHPR
LPLETVMELF RKIGPRVILI EHRGRLAGLV TVKDCLKYQF KVEAAEQPRD GDDGFAEAQE
KLWGIMTRVA DWVSGKVSTA SGGRIRLRDS FEGSRSSEKN VQRQIRHEL
//
