ID A0A421F7Y6_9STRA Unreviewed; 1619 AA.
AC A0A421F7Y6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN ORFNames=BBI17_001577 {ECO:0000313|EMBL:RLN27179.1}, BBO99_00001806
GN {ECO:0000313|EMBL:RLN83817.1};
OS Phytophthora kernoviae.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=325452 {ECO:0000313|EMBL:RLN27179.1, ECO:0000313|Proteomes:UP000285883};
RN [1] {ECO:0000313|Proteomes:UP000285624, ECO:0000313|Proteomes:UP000285883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chile2 {ECO:0000313|EMBL:RLN27179.1}, and Chile4
RC {ECO:0000313|EMBL:RLN83817.1};
RA Studholme D.J., Sanfuentes E., Panda P., Hill R., Sambles C., Grant M.,
RA Williams N.M., Mcdougal R.L.;
RT "Genome sequencing of oomycete isolates from Chile give support for New
RT Zealand origin for Phytophthora kernoviae and make available the first
RT Nothophytophthora sp. genome.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLN27179.1}.
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DR EMBL; MAYM02001057; RLN27179.1; -; Genomic_DNA.
DR EMBL; MBDN02000027; RLN83817.1; -; Genomic_DNA.
DR STRING; 325452.A0A421F7Y6; -.
DR Proteomes; UP000285624; Unassembled WGS sequence.
DR Proteomes; UP000285883; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 2.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 2.
DR Gene3D; 2.60.120.10; Jelly Rolls; 3.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR SMART; SM00100; cNMP; 2.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 3.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 3.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000285624};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 1251..1270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1384..1405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1467..1487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..582
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 788..876
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1151..1199
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1619 AA; 184193 MW; 78DB1BC2A57561C2 CRC64;
MPSVSPRGAP PGRKRSQPEE QERERTIQQH TTPCVGVAPS KRRRSDAEGD APVQDQDQGT
DLGQDSGPNQ EQDEKLDGAP QGELFVVTVR SREELQPCQD EKLQAEKLDA LLAKEKAETE
TDVAWGHEFA ALDSLRCFAM FHQDEARRQL ENGVLKKLVM PAAMSLRSAM ARNALLCVQD
LILGLQTEIA SHFDAIVPIL LNRACSEKQF IRDLARDVLD TALEASADEA LLEPLLSTST
MEKNAQIVNV AGLYVAKCIG RMDRTRLRLF ILETRGSFFD EMAAFLRCKV VECKAATRRT
CQHTRRIIGN ETFVALAKEK LSGSTQLDVL KASEVRKAAK PGHAKSSIRE RMLQLKKQQQ
QQKKAGNIHR DKRTARAKYL KSLDFFLDVL AIIPLSLILP PSMARCSQES NQTVLAQARI
NQLRHLLTFH HVPEPLQIQA VEYLKRHYTD AESNDREVVK LLCPSITKDI QVELLKDMVG
RIPLFRGCNQ QFIVALTSLL EMTSFPAHVT LFEAGDPGDY MYVVNSGVLH ILVNGVKVRE
LRQGSFFGEV SVFSKRPRSA AVVTTSYCTL YRLSRFHTER VLEGYPNYAS QIASTIDEMV
NEQEGKVSEG REVRDGGEEF MLTTLTSSRP DTMQGFYDNL ARRRVSHQQA TDALSKALSN
LLMRRAIDFS SQWRKYWLIA LQVHLVANCA QSRFTASAFE QKEFLVTRSR IQQFIRSRTA
PPGVHQRVQS FLEFWWSSHR GAIAGELLNE LPEAIKRPVV RSMCQPALRT LSLLAGVRTS
LDALEQVFID NIRFILYGQG EIIYRQGDYA SGLFFLLEGE LIIIANGGTP RTLVNGGFIG
TAALNLSETS VSYAERVTAA SGCILIFVSR EHLNGIHKAF PSFSMAIRAL ENRLESAKLA
RAQQEYSGRE RSWSGGQLPT PSLKKLTVEM KLLQHLGLES LVFDPDTRSS AGWELWIFGL
TIALYLKVIT DIMAGVKDGD VVRSEVIAVL FEIFFAFDFY FHSRLGFYEY GNKSMDVGLI
RKRFFRSRHC YCDALALIPL YVVNWMVPLA RRHDLLSINK LLRLMRTPTA FAKLEIDADS
REFNSKLSSL RLLLGHFHLP LAIEEQLKTY FFFQRYHTIT QEHLLERCLP PSLLTEIRLV
HLQPMIVKVG FLAGMEGSVT RMLVSQFVQV LTVKDQFVFR LGEEGSDMFF VFTGIIEVLV
PLETLQRRQS NDAKLGSLGS PSRSSFRTFF HPLDPSKLQA RSQLKKSAFH LQWLKTIAVG
TICMALVVPY RNAFDSLERL SPMPITERIV ELTCEVLFAW DIWVNWNLKD GLESMELYEH
KHRDTYQKER LWIDIIAAIP IDHFLSDFYQ SPLLCLNRCL KLFNFPHYMK EINRRSVSYE
KNRLCTLWVL LFVLMHWCAC VYFALATRKA DGDGNVQDWD SWTPPHLVVS WSDPSQELLM
LRFLRGIFFS FTAFIKKGKV FVPVNYADYL FTLLVDFIGL VTMAFMISEM ANLYISYISN
EVEFRKNYIA VGLYLDRWNI TGQLRARSHA FLSSLWISHR GVNYQAIFDE IPQVIHTESI
LHIANLPLRA FINTVFRPFA TPHPHDRELE ALTHAIAQHL KYEGYPRDEP TSGISSPAA
//
