ID A0A421J9F9_9ASCO Unreviewed; 1019 AA.
AC A0A421J9F9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=JA9_001878 {ECO:0000313|EMBL:RLV85455.1};
OS Meyerozyma sp. JA9.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=2028340 {ECO:0000313|EMBL:RLV85455.1, ECO:0000313|Proteomes:UP000286412};
RN [1] {ECO:0000313|EMBL:RLV85455.1, ECO:0000313|Proteomes:UP000286412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA9 {ECO:0000313|EMBL:RLV85455.1,
RC ECO:0000313|Proteomes:UP000286412};
RA Formighieri E.F., Steindorff A.S., Trichez D., Almeida J.R.;
RT "Physiological and comparative genomic analysis of newly identified yeasts
RT Spathaspora sp. JA1 and Meyerozyma sp. JA9 reveals insights into xylitol
RT production.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLV85455.1}.
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DR EMBL; NSDU01000013; RLV85455.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A421J9F9; -.
DR STRING; 2028340.A0A421J9F9; -.
DR Proteomes; UP000286412; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF1; PROTEIN HIR2; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000286412};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 8..40
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 736..963
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 141..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 113273 MW; AF021A87EAA382AC CRC64;
MKAIVFPTSL HAGEVHTADI SSDGARVLTG GSDGAVSVYK YADFRAFDMS KPCSLTPVKT
VELDSTVTVG RFCPTDADII AVGTINGSVY LVGENTLVCI FPLSKWNVVQ PTNTGEVKAY
NAPPNDKPVL AKAPEELTSS GLEKTPELAT LTDKSEKSPP AKPSHTSIST PNILDVAWSP
DGRLVAWISA FEVHIHDRSK NTYQTLITSK PNSSPRSIAF DPTSSFFVCL GDDTVIDIYR
YHYKNDMYQF KHFTTNSRMA NAVPNIVNYR RISWSPDGEY VSVPTASKGQ TSLVSLISRS
SQWSAKVSLV GHDTCCEVVR FNPTIYAWDG GDSKTGIPPV EKPLEPNAEP TNDDSNDNNA
EDARPHFVYN IVATAGSDMT LSVWNTIKEK PLLLLKDIAT KPISDLVWHP NGQSLLQSSM
DGHITLYNFE DHELGNPASK TINNQLLEFS KKIIHPFEYT QPVEGATKKP PPPVIIDQKN
ATEQNSKPDQ EAESVADAAP STAHETKKEK QVPEDEDIRP VVLEPSTGTD TSQHSFLNEA
PIIKRPKLTS QEPAKLSKQK VSTKDGKKRI QPMLISSTNG SSNTTPLSSN GHDMWNNSNT
PSLPMEYEKP SYVVADSVSR KRPKNDDSTK KKRELEPIKF IGSQLQNPNT AFAAIRLAVP
KVRLSFQIEQ NESAFLDVKN GSGNESTPTR LTYVRNDRQL WTDFIPRYVL LATKGTNFWA
TATADGEIYT YVLESGKRIF PPIVLGSAIS FLESHEQFLL AITSVGELYV WDLNEKRIVL
HSPQSVKALL DLSSKYEEDV LSKSENITMC SVTSKGIPLI TMSSGSGYLF NKDLGVWHIV
TESWWAFGSH YWGSLAYNRT SSDSAKQEES IIALLEQKTN EEILRKSRTG RGKFMNKISK
NMIMKEGFEN LENSISINHL ENRMLASELL GEKDDFHAFF LTYVRRISEL GLQAQLLGIC
SELYGPEDMK SNGWKPEICE WDKRALLKEL VLTCAKYRNV QRILVHYAEK IGVVSEMYG
//
