ID   A0A421JDR6_9ASCO        Unreviewed;      1109 AA.
AC   A0A421JDR6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   22-FEB-2023, entry version 13.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=JA9_001296 {ECO:0000313|EMBL:RLV87172.1};
OS   Meyerozyma sp. JA9.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=2028340 {ECO:0000313|EMBL:RLV87172.1, ECO:0000313|Proteomes:UP000286412};
RN   [1] {ECO:0000313|EMBL:RLV87172.1, ECO:0000313|Proteomes:UP000286412}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA9 {ECO:0000313|EMBL:RLV87172.1,
RC   ECO:0000313|Proteomes:UP000286412};
RA   Formighieri E.F., Steindorff A.S., Trichez D., Almeida J.R.;
RT   "Physiological and comparative genomic analysis of newly identified yeasts
RT   Spathaspora sp. JA1 and Meyerozyma sp. JA9 reveals insights into xylitol
RT   production.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RLV87172.1}.
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DR   EMBL; NSDU01000008; RLV87172.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A421JDR6; -.
DR   STRING; 2028340.A0A421JDR6; -.
DR   Proteomes; UP000286412; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286412};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          45..317
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          621..1062
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1109 AA;  123809 MW;  5A478EC8E179528E CRC64;
     MSQSTQLSTT ISQYIASPDE EDGRPFSRSL ASILSSRSST LLQFIQGLGP ILTSESELAR
     SKALECLATT LEEVDPAVIS KQDVSVLIDF LIAKLDDTTC VQYVLRALIT IIKLSSFKPG
     VNGNLEKVVT ALSTKYDPRK YLAKVRYHSF NLIHTALETH NAFILSHQAE IAQKIVEAFI
     HIASGEKDPR NLLISFAINT KVNTMFEFNP TTHKQLINDL FDVCFCYFPI TFTPPPNDPY
     KIKAEDLKSS LESTIASQSL FASDAFSGLL EKLTSTNPVV RNDVLRTLHL CVANYQSDVV
     LAHWLSIWSA LKFEILHNDV SIFPSTATAI IPEGYELIDD TDDNKVLIQT LAVIRELQKQ
     IIKQDVYQHK HLENGDHDFD YTNKFLESVT ADLKESVATV SKSFRQAVII LALLGAESPE
     SFSFIVGFLF SPKILGKYIG GDELQSDMEM DINESAILNV AKQRELIDCL GFVFISFRLL
     TAAGVSEEFM KSNSLLVYKE HLLLFLGQLL QTTSNIEKTL KCKIVQQLTA LVQLPGLLTV
     QEVTLIFGYF KDIMSQLERE NPDSWDEDIV VKEIIKGSVS VVEDTTPING PKKTVVTETL
     LPFLMDLIVP EASSNAIGKA LGVIKCLSMN HQFLEVVSIR LSNKITHFLQ SNISTEEKAD
     AFKEICSTLS DSILNTQANF QFSTNSWYKN FVPRFLRSFF ELWSQNRQPD VAAVEAAGTL
     VGIIVRFLDK PKHQTSLNEL TSLFLLPQNN FQLPAVQISV SSSPLVGLFN QIIANIDKTV
     SFEEAISPLV VSELISDITS RCQDSEKDNG YTRLCYLQML AILSNKLVKD ATLFDPFLQP
     TFDEISIETG KLPLSKVERF EVLVWITKGL VMKLDQRGMG FTQKLVSLLS NTNNEVQQLA
     SKCLGILVCD LPIFTISSTS KKQVKLGSGV TPTNVRLLYK QRLFDTLLPL LIAGYQDTKD
     EVYLVSLSIL VENVSSSLLK GHLNELSSMV ISSLPIDNSV IVGSALKTLK ILIDEAPELV
     KPHLNNIIER LIALVVERIV VGKKLVNAEN VRCEALVCLS KIFQNIELEY TVPYQKGTIK
     KLEPALDDKK RSVRKHCCDL RQVLYELGR
//