ID   A0A421JJX0_9ASCO        Unreviewed;       351 AA.
AC   A0A421JJX0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 9.
DE   SubName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase decarboxylating {ECO:0000313|EMBL:RLV90695.1};
GN   ORFNames=JA1_004385 {ECO:0000313|EMBL:RLV90695.1};
OS   Spathaspora sp. JA1.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Spathaspora.
OX   NCBI_TaxID=2028339 {ECO:0000313|EMBL:RLV90695.1, ECO:0000313|Proteomes:UP000285775};
RN   [1] {ECO:0000313|EMBL:RLV90695.1, ECO:0000313|Proteomes:UP000285775}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA1 {ECO:0000313|EMBL:RLV90695.1,
RC   ECO:0000313|Proteomes:UP000285775};
RA   Formighieri E.F., Steindorff A.S., Trichez D., Almeida J.R.;
RT   "Physiological and comparative genomic analysis of newly identified yeasts
RT   Spathaspora sp. JA1 and Meyerozyma sp. JA9 reveals insights into xylitol
RT   production.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RLV90695.1}.
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DR   EMBL; NSGQ01000047; RLV90695.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A421JJX0; -.
DR   STRING; 2028339.A0A421JJX0; -.
DR   Proteomes; UP000285775; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   CDD; cd09813; 3b-HSD-NSDHL-like_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000285775}.
FT   DOMAIN          11..281
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   351 AA;  39140 MW;  4AD52D28E8F73435 CRC64;
     MTKSPLNSVL LVGGSGFLGL HLIEQFYRHC PETKITIFDI RPLPEKLSKY FTFTPNQIQF
     IKGDLTSESD ISQAITTSEC DVIVHAASPM HGLPQEIYEK VNVEGTKNLL VQAKKLGVKA
     FVYTSSAGVI FNGQDVYNAD ESWPYPDVHM DGYNETKAIA ETEVMNANDP SRGFLTVCLR
     PAGIFGPGDR QLVPGLRASA KLGQSKYQLG DNNNLFDWTY VGNVADAHVL AATKILDPEF
     SQQLGGETFF VTNDSPTYFW TLARTVWKAD GYIDKYYIKL NRPVAIVLGY FSEFFSKLAG
     KEPGITPFRV RVVCATRYHN ISKAKTILGY KPAVDLETGI KYTLDWMNED I
//