ID A0A421JPN4_9ASCO Unreviewed; 349 AA.
AC A0A421JPN4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000256|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000256|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 39 kDa subunit homolog {ECO:0000256|HAMAP-Rule:MF_03008};
DE Short=eIF-3 39 kDa subunit homolog {ECO:0000256|HAMAP-Rule:MF_03008};
GN Name=TIF34 {ECO:0000256|HAMAP-Rule:MF_03008};
GN ORFNames=JA1_002672 {ECO:0000313|EMBL:RLV93140.1};
OS Spathaspora sp. JA1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Spathaspora.
OX NCBI_TaxID=2028339 {ECO:0000313|EMBL:RLV93140.1, ECO:0000313|Proteomes:UP000285775};
RN [1] {ECO:0000313|EMBL:RLV93140.1, ECO:0000313|Proteomes:UP000285775}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA1 {ECO:0000313|EMBL:RLV93140.1,
RC ECO:0000313|Proteomes:UP000285775};
RA Formighieri E.F., Steindorff A.S., Trichez D., Almeida J.R.;
RT "Physiological and comparative genomic analysis of newly identified yeasts
RT Spathaspora sp. JA1 and Meyerozyma sp. JA9 reveals insights into xylitol
RT production.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the WD repeat STRAP family.
CC {ECO:0000256|ARBA:ARBA00038394}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000256|HAMAP-
CC Rule:MF_03008}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLV93140.1}.
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DR EMBL; NSGQ01000018; RLV93140.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A421JPN4; -.
DR STRING; 2028339.A0A421JPN4; -.
DR Proteomes; UP000285775; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19877; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I; 1.
DR PANTHER; PTHR19877:SF1; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_03008};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_03008}; Reference proteome {ECO:0000313|Proteomes:UP000285775};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 6..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 48..89
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 134..193
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 294..324
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 349 AA; 38275 MW; 4BD1D13A37E79D43 CRC64;
MRPIKLMGHE RSLTQVKYNR EGDLLFSVAK DNAASIWYSS NGERLGTLEG HQGVIWSIDV
DPETHLCVTG GGDLAIKLWK VENGQCLFTW DSPSPVRRVA FNNDGSKLLA VADQVMGHIG
TISVFEINQN DASLANQNSE PVLVISTEQG GSKVTVAGWS GDNKYIIAGH DNGYVSKYDA
QTGELVQTVQ AHGIHNEEKI VYITDIQFAP EDKSYFITSS KDKTAVLIDV DTFEPLKVYK
ADAPMNTAAI TPVKDFVILG GGQEARNVTT TAESQGKFEA RFYHKIFQDE IGRVKGHFGP
LNTVAVHPDG SGYSSGGEDG FIRVHTYDKS YYDFLFDAER TEKVDAAAI
//
