ID A0A421JT07_9ASCO Unreviewed; 1338 AA.
AC A0A421JT07;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Vacuolar cation-chloride cotransporter 1 {ECO:0000313|EMBL:RLV94909.1};
GN ORFNames=JA1_001402 {ECO:0000313|EMBL:RLV94909.1};
OS Spathaspora sp. JA1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Spathaspora.
OX NCBI_TaxID=2028339 {ECO:0000313|EMBL:RLV94909.1, ECO:0000313|Proteomes:UP000285775};
RN [1] {ECO:0000313|EMBL:RLV94909.1, ECO:0000313|Proteomes:UP000285775}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA1 {ECO:0000313|EMBL:RLV94909.1,
RC ECO:0000313|Proteomes:UP000285775};
RA Formighieri E.F., Steindorff A.S., Trichez D., Almeida J.R.;
RT "Physiological and comparative genomic analysis of newly identified yeasts
RT Spathaspora sp. JA1 and Meyerozyma sp. JA9 reveals insights into xylitol
RT production.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. YAT (TC 2.A.3.10) family. {ECO:0000256|ARBA:ARBA00006983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLV94909.1}.
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DR EMBL; NSGQ01000007; RLV94909.1; -; Genomic_DNA.
DR STRING; 2028339.A0A421JT07; -.
DR Proteomes; UP000285775; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF72; GH08340P; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000285775};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 73..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..560
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1104
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1338 AA; 149032 MW; D3958192B5E76D4F CRC64;
MTSIGVSSPR YPPNETTQLL LPNRSRNSTS QRTTPRSARA TSKPSNNVGD SKSKEKDNKS
KGTKNKLGTF EGVFLPTSLN VLSILMFLRF GFIIGQMGIL GTMFLLILSY SINILTTMSV
SAIATNGTVK GGGAYYMISR SLGPEFGGAI GIIFVIGQIL NSSLNVVGFI EPFLVNFGLE
GGDMAKLLPT GYMWSVLYST ILLFICTGVA MVGSSLVSKT ALFLFIILTI STLSIPISTL
FVKPYHPLPS PFEDILYTGL TWKTFTDNLY PKFTSGAAGS VLPSGVPETF RDLFGIFFPA
TAGILAGASM SGELKTPSKS IPEGTLKGLL ITFILYTLVI VSMGSAIPRE LLHVDIKVIQ
TVNLSSIIII LGEFSTSLFS VIMGIVGASS MINAIADDKI IPGLSIFTTS KKSLKDQKRA
QIWSIIMTWF IAQIFLFADI NQIATFITMA FLMTFIVTNI ACFLLKIGSA PNFRPSFKYF
STRTAFTGAV VCFIAMFIVD GISATLVIFC LTFFILMIHY STPPSKFGDI SQLLIYHQVR
KYLLRLKLEM SVKYWRPQIL LLCDNPRTSW NLIGFCNHLK KGGLYVLGHV VMMNDDTMPE
SNNSRNNSVF SVNTYKEVRK QKQAWVKLRD MSKVKAFVQI ALGPTLPWGV RNVYLGSGLG
GMKPNITVLG FYDFIKHGIE MPIIPSTEQV EQGQLPTDTC RKEKKVSIGQ WVQIVEDLII
LQATVAVAAN FSKLKLPKSE NNEGSSFWKS MFQSPHVVDK DSKKYIDLYP IQMSSINQLD
NGQSVLSTNF DTYTLILQLG WILSTVQEWK LNNFKLRVIV FVESKHEVED ETTRLSKLLS
TLRIKAEIKI VCLDDGSLDS YNYMVKGYTK TQSNRQACEK VDNILHDEQW WINLSNARET
LVEIEKKKAA RKKKIMMKLD SSRNASTASL VNNGVEEFYP LDLNSSPLNS RSPFEQFKNN
RRYTLSNLQE QGMALSFNLR SQTAHQFLDY EDPISDSSDE EDTSNSVTNS MLNLSSYSSL
DRMTPEQSLT APPPSSTPQL APAPQKHYRP TLKDSIDNSS FKSSDQLSIR SSNLRPNFSS
LKIPESQIND DEDGDEENAG EDESGDNEGE PRVAKQTIQF VVEEEDEEEE DNQEDHPLEL
TVPGTRNKEK PVSRKRASSK VRDSPGKSPA IFANDDGIIK QMRTPQFLAE EEDDDVPPLS
PMDRSYRASA GPSGSREQFY KARTKQQQPQ AQPQTQAPPA PEDKKTITRR ELQEEINRLS
FDDIPAKGQH IVLNELMKRN SLHGETYVIF STLPAPTMGT HLDEGESFEY TNNLAVWLDD
LPPVMLLNSQ TVTVTTAL
//
