ID   A0A421JW52_9ASCO        Unreviewed;      1014 AA.
AC   A0A421JW52;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Autophagy-related protein 6 {ECO:0000313|EMBL:RLV96309.1};
GN   ORFNames=JA1_000362 {ECO:0000313|EMBL:RLV96309.1};
OS   Spathaspora sp. JA1.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Spathaspora.
OX   NCBI_TaxID=2028339 {ECO:0000313|EMBL:RLV96309.1, ECO:0000313|Proteomes:UP000285775};
RN   [1] {ECO:0000313|EMBL:RLV96309.1, ECO:0000313|Proteomes:UP000285775}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA1 {ECO:0000313|EMBL:RLV96309.1,
RC   ECO:0000313|Proteomes:UP000285775};
RA   Formighieri E.F., Steindorff A.S., Trichez D., Almeida J.R.;
RT   "Physiological and comparative genomic analysis of newly identified yeasts
RT   Spathaspora sp. JA1 and Meyerozyma sp. JA9 reveals insights into xylitol
RT   production.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC       {ECO:0000256|ARBA:ARBA00005227}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RLV96309.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NSGQ01000002; RLV96309.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A421JW52; -.
DR   Proteomes; UP000285775; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR   InterPro; IPR038274; Atg6/Beclin_C_sf.
DR   InterPro; IPR041691; Atg6/beclin_CC.
DR   InterPro; IPR040455; Atg6_BARA.
DR   InterPro; IPR004240; EMP70.
DR   PANTHER; PTHR10766:SF55; TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4; 1.
DR   PANTHER; PTHR10766; TRANSMEMBRANE 9 SUPERFAMILY PROTEIN; 1.
DR   Pfam; PF04111; APG6; 1.
DR   Pfam; PF17675; APG6_N; 1.
DR   Pfam; PF02990; EMP70; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000285775};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        919..941
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        981..998
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          164..314
FT                   /note="Atg6/beclin coiled-coil"
FT                   /evidence="ECO:0000259|Pfam:PF17675"
FT   DOMAIN          318..470
FT                   /note="Atg6 BARA"
FT                   /evidence="ECO:0000259|Pfam:PF04111"
FT   REGION          75..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          244..307
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        81..96
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1014 AA;  116655 MW;  16EDADF17D4C9112 CRC64;
     MSQEGDLTCK KCDTPLILDD SLKKVNLTQL SRLVNKRQPR QEEPNILNPQ DYIPQDRLNL
     YEYVSSKKHN IEPIQYRNYL ESEDEEEEEG EPEGEDERSG EASGMDSSST DNSYLLVLEE
     SEEEFDYANK QSETEDREIR ISNRIKTLNK VFEILSNNQD IDHPLSEDCA NLLIENYKLK
     FDQNQREKDS YLSFLRKLKD KDNQLKIYEE EGDTVKFNPE LFKKDLDKKL KDSIEEFERL
     TILEQQSLEE LKQLEATKSE LEVDLKQYKQ ELQEIESVKL TEILQQKNKL QLELQDKENK
     LEQSKAAYHV HLDHIDKLRN LNIYTKIFNI TSDKNNKYGM INGFRIGYKV IRSEINAALG
     QIVLLLIFMI KRLNLKLVNY KLVPMGSQSQ IVKFTEEEQG EETTTKSKTV LNLYSTDEFS
     LGKLFNFNKL DVAMISLLDV VSQIDARLIS LDSEIELPYK ISPRKDSIGV KRSDIVIVNE
     DSVPKSNQRI IPIKSEPEEI ATNWIKLNHT NSNGNRSSPN DRLVLNFPNR FVEGSVNYGL
     PSNVNTSKSP SQIHLIQSSP MLNKGNSTEL EVDTGFLSGE YSVNQDELLQ AQNVYRNLFG
     ESPSVSNNSS SINLKDNKLD SSIIKKEEDQ YPSINAKDNK LDSSVIKKEE DQYPDMISLS
     QSKENSFIQP TPVVETIPKK KTRRKRRRNY RLQINKKVRK PPTMFVVLKV TNKVKFLRAI
     NHRSFSGPRK QSESLGSILF GDRIFNSPFD IKMLQEKSCE KLCTSKYSKS DSVFVNRNIR
     ASYNHNWIID GLPVASVIKD ARTDTTFYGP GFHIGEVDNK NNAHLANHFV IIIDYHKRGD
     NKFRVVGATA ERYSLDRTGV PADAGADQIC SLDLPQVLLS KEKESDVLFT YAVQFRESDV
     AWATRWDKYL HVYDPKIQWF SLINFSLIVS ILGIIIGHII VRTLKNDIVK YNEVNLDDDI
     SDESGWKLVH GDVFRPPKQR LLLVLLILLP VLPPFTGIET ELELLLEDVE FGIS
//