ID A0A422PQ12_9TRYP Unreviewed; 512 AA.
AC A0A422PQ12;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=SAM-dependent MTase RsmB/NOP-type domain-containing protein {ECO:0000259|PROSITE:PS51686};
GN ORFNames=Tco025E_04072 {ECO:0000313|EMBL:RNF19833.1};
OS Trypanosoma conorhini.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=83891 {ECO:0000313|EMBL:RNF19833.1, ECO:0000313|Proteomes:UP000284403};
RN [1] {ECO:0000313|EMBL:RNF19833.1, ECO:0000313|Proteomes:UP000284403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=025E {ECO:0000313|EMBL:RNF19833.1,
RC ECO:0000313|Proteomes:UP000284403};
RX PubMed=30355302; DOI=10.1186/s12864-018-5112-0;
RA Bradwell K.R., Koparde V.N., Matveyev A.V., Serrano M.G., Alves J.M.,
RA Parikh H., Huang B., Lee V., Espinosa-Alvarez O., Ortiz P.A.,
RA Costa-Martins A.G., Teixeira M.M., Buck G.A.;
RT "Genomic comparison of Trypanosoma conorhini and Trypanosoma rangeli to
RT Trypanosoma cruzi strains of high and low virulence.";
RL BMC Genomics 19:770-770(2018).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNF19833.1}.
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DR EMBL; MKKU01000195; RNF19833.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A422PQ12; -.
DR OrthoDB; 8499at2759; -.
DR Proteomes; UP000284403; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22807:SF16; S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 2.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000284403};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 59..504
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 388
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 176
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 203
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 297
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 512 AA; 56370 MW; 071CB2054FCAC43C CRC64;
MDAPYDAATP EYPETFTEDF VRYCRSHHLP PQLFYELSKV LETIPRYIRL RPQRMRDLVT
PAEEDNVALE DATSRRRCQI KAGIAASFGI SSASVEEVEW LPDPYCYAVP RGVAMCRAAL
YQSGTVSAMD AASMAAVVAL RPSQGDLVWD VCCSPGMKMS LIADAIGEAG VAVGTDISLP
RLFTARSVLK KHPVGNVCLF AADGTSFSLK AAAAALDETP SSPKGGRNGL TLWEERQLRR
LQKRQHESTV GAAATSSGVK VENKIMVAFS TDPARERLYR IVDRMNEDHG FDRVLVDAEC
SHDGSLAHIF LSDATRKPFA AGEDALTPAP AGIDNAHRMQ RLNLALQPDN TDPELREGSS
ALMRLQLGLI QNGYAQLKPG GTLVYCTCSF TYQQNELVVQ EAVSRVNSSK EMKQQYKGEA
VICHPFSYTH ETVSPESISP IVRLTDAQAK YLQQRLKEDA DPYGICLAGE EESSNAGRHI
FTGVRFWPRA FATSFQFIAK IWKRPLPPSS NE
//
