ID A0A423SFT5_PENVA Unreviewed; 852 AA.
AC A0A423SFT5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE SubName: Full=Alpha-2C adrenergic receptor {ECO:0000313|EMBL:ROT63055.1};
GN ORFNames=C7M84_019070 {ECO:0000313|EMBL:ROT63055.1};
OS Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6689 {ECO:0000313|EMBL:ROT63055.1, ECO:0000313|Proteomes:UP000283509};
RN [1] {ECO:0000313|EMBL:ROT63055.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT63055.1};
RA Zhang X., Yuan J., Li F., Xiang J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROT63055.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT63055.1};
RA Sun Y., Gao Y., Yu Y.;
RT "The decoding of complex shrimp genome reveals the adaptation for benthos
RT swimmer, frequently molting mechanism and breeding impact on genome.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT63055.1}.
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DR EMBL; QCYY01003501; ROT63055.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A423SFT5; -.
DR Proteomes; UP000283509; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd14967; 7tmA_amine_R-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF268; MUSCARINIC ACETYLCHOLINE RECEPTOR DM1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:ROT63055.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000283509};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 542..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 555..830
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 79..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 93585 MW; 306BE15795766F95 CRC64;
MSLLALEAPN ITQEYTGGGT GLPLPDEALL HLNMSRDAEA RDISTFHNRN SLLWSLLMSA
TMATLEPGTV SGSVTLPFNT TSVPGDPPGG TGATGDGQEE DGVTLDGGAT LNLFPWTTTA
DLDPGGTMGD GTATEKSKAE DMNLIVTSQL LQVSGEDKTA SPSPSLDVPD LDAATGTGTE
KTFKGSKQPP PPEEEKVSEA EAGLPPRNQT DSEDRLQESL LDSPNEASNR SQVDIENKNY
LDLSNDPLIT AMSLSNLTQL MASSMNENAT AQYDATTAPE TSVPNTTEVG ETTEENSGSS
EPLRIVNEPS TTSNHRHDPL LITQGSSIPE SRTSQNADSA PEFSQALSLL PDDTPSTKLN
DAPHPNTGDL DKVVSQPQVI GRPDADGPPV WGTSADGQQV RTAFPHSLDV IIVEAHTHQT
ASKPSGLSKN SALSQVHQPF QSSVPETHDL GVQEEHPAFQ TFRPVSQNIN LKTQQPLSNA
EISSGLEDPI PEVETDDSDI FQNVSDALLS ETNSSDSNAT AMGEEAAALG GINWTPFKIT
LFIIQFIIMV ETVLGNLMVI LSVKMEKKLQ TPFNYYIVNL AFTDMNVGLS VMSLFMINNL
YDYFPFGSFL CNYWIWSDYV MTFESVMTLA AISVDRLWSV TWSLHYRNNN NGKKSMLIII
ATWLYVSVLW FPAFIYDRVL HHYDDGVCYW DPVLNKNLVV YVGMLGYYLP LLVMVGAYMK
ILHVVKKRAA SIRDAGKKEV PTKKLVSGAA KDDKQEAKLK REMKAVYTLL NIVIIFLICW
VPFYILFVPI KRDTFSFQLS AWFPTLFPEW YLTFSYWMAY INSALNPILY PLSSLEFRAA
YKKVFYTVFC GK
//
