ID A0A423T6F6_PENVA Unreviewed; 516 AA.
AC A0A423T6F6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=hydroxyisourate hydrolase {ECO:0000256|ARBA:ARBA00012609};
DE EC=3.5.2.17 {ECO:0000256|ARBA:ARBA00012609};
GN ORFNames=C7M84_009623 {ECO:0000313|EMBL:ROT72003.1};
OS Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6689 {ECO:0000313|EMBL:ROT72003.1, ECO:0000313|Proteomes:UP000283509};
RN [1] {ECO:0000313|EMBL:ROT72003.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT72003.1};
RA Zhang X., Yuan J., Li F., Xiang J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROT72003.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT72003.1};
RA Sun Y., Gao Y., Yu Y.;
RT "The decoding of complex shrimp genome reveals the adaptation for benthos
RT swimmer, frequently molting mechanism and breeding impact on genome.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-
CC 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
CC {ECO:0000256|ARBA:ARBA00002704}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-
CC dihydro-1H-imidazole-5-carboxylate + H(+); Xref=Rhea:RHEA:23736,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18072,
CC ChEBI:CHEBI:58639; EC=3.5.2.17;
CC Evidence={ECO:0000256|ARBA:ARBA00001043};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the transthyretin family. 5-hydroxyisourate
CC hydrolase subfamily. {ECO:0000256|ARBA:ARBA00009850}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT72003.1}.
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DR EMBL; QCYY01002217; ROT72003.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A423T6F6; -.
DR STRING; 6689.A0A423T6F6; -.
DR EnsemblMetazoa; XM_027363177.1; XP_027218978.1; LOC113811440.
DR Proteomes; UP000283509; Unassembled WGS sequence.
DR GO; GO:0033971; F:hydroxyisourate hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05822; TLP_HIUase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.60.40.180; Transthyretin/hydroxyisourate hydrolase domain; 1.
DR InterPro; IPR014306; Hydroxyisourate_hydrolase.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000895; Transthyretin/HIU_hydrolase.
DR InterPro; IPR023416; Transthyretin/HIU_hydrolase_d.
DR InterPro; IPR036817; Transthyretin/HIU_hydrolase_sf.
DR InterPro; IPR023419; Transthyretin_CS.
DR NCBIfam; TIGR02962; hdxy_isourate; 1.
DR PANTHER; PTHR10395:SF7; 5-HYDROXYISOURATE HYDROLASE; 1.
DR PANTHER; PTHR10395; URICASE AND TRANSTHYRETIN-RELATED; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF00576; Transthyretin; 1.
DR PRINTS; PR00189; TRNSTHYRETIN.
DR SUPFAM; SSF49472; Transthyretin (synonym: prealbumin); 1.
DR PROSITE; PS00769; TRANSTHYRETIN_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ROT72003.1};
KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW Reference proteome {ECO:0000313|Proteomes:UP000283509}.
FT DOMAIN 18..101
FT /note="NACHT"
FT /evidence="ECO:0000259|Pfam:PF05729"
FT DOMAIN 436..515
FT /note="Transthyretin/hydroxyisourate hydrolase"
FT /evidence="ECO:0000259|Pfam:PF00576"
SQ SEQUENCE 516 AA; 59459 MW; 9CA7F4EEFD3C3AA4 CRC64;
MPCASYSMSN EDIVRSVLAL RVLLILDGLD ELNKASRQLV EEIVMDKMPK STGVFHLLLT
TRPQALRELP NYCIKSEWIH MRILGITAEQ RPEFVYKLHE EMKKEKMSQQ DTQKLMDYVK
KSEARLGEHF RLPLNLTLLT YLWAASPEDV NSVTTATHLF LRILELIKKR LVNRLVDKLY
CSWDEISDHV TEYMEVLYEK SFEEIINDSL QLSESSEQAL KKKCKALELP FQEMSAAFMN
VTREWTAGGY ALHLTAPHKS IMEFFAAEWI HTCLMRNGAK TLKNILEELK CDESSLPKYQ
NVLLHLCGLL HENGKCTLDQ HAEELVQLLT KSETTEQQWL DIIAESECNE TIVKLIAPRI
GTKLIVRDGH TGAAASIFSH LPESTPVKVI LNCEITHIPH LDNFIDELSK RHCYVELHFR
HQWKNMQCGN STDRLKQLSK SKATNSDGRA GQFLSQEAFT PGTYKMFFDT GNYFKQQGTT
GFYPYVEIVF VIERPEEHYH IPLLLSPYGY TTYRGS
//
