ID   A0A423TH14_PENVA        Unreviewed;       700 AA.
AC   A0A423TH14;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN   ORFNames=C7M84_005693 {ECO:0000313|EMBL:ROT75752.1};
OS   Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=6689 {ECO:0000313|EMBL:ROT75752.1, ECO:0000313|Proteomes:UP000283509};
RN   [1] {ECO:0000313|EMBL:ROT75752.1, ECO:0000313|Proteomes:UP000283509}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Muscle {ECO:0000313|EMBL:ROT75752.1};
RA   Zhang X., Yuan J., Li F., Xiang J.;
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ROT75752.1, ECO:0000313|Proteomes:UP000283509}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Muscle {ECO:0000313|EMBL:ROT75752.1};
RA   Sun Y., Gao Y., Yu Y.;
RT   "The decoding of complex shrimp genome reveals the adaptation for benthos
RT   swimmer, frequently molting mechanism and breeding impact on genome.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROT75752.1}.
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DR   EMBL; QCYY01001737; ROT75752.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A423TH14; -.
DR   STRING; 6689.A0A423TH14; -.
DR   EnsemblMetazoa; XM_027357653.1; XP_027213454.1; LOC113806513.
DR   OrthoDB; 1330770at2759; -.
DR   Proteomes; UP000283509; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000283509};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..700
FT                   /note="Nicastrin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018980088"
FT   TRANSMEM        663..683
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          43..221
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   700 AA;  78856 MW;  3D45935ED22F5CFA CRC64;
     MASKVTGRQA TLLRVLVLSG TFFLAAGERV KNKIYDEIQG DMACFKRFNG THEIGCTSKF
     FGNTGVLHVI EEKADFDWVY EHGPHQPYVL AFTPLFLTEA VLERATDSGK VSGVVVVVPE
     DFDPETQLLD GFSGETECPD AYLGLYNASS NPDYAGYCRK KPWNPNGTSM LYTSWEFPIF
     LITNQTSVNN IQNCFEKFNK PVNGMPRDWP LCSLELKSNM YGTTNSEVCM RRASIGPLST
     DNFCDPLYDY NIWGTLKPMN MSEEIPEKSV IIVAARMDAA TMFDNISPGA NSAVSGIITL
     MSAAAAIFKH KEEIINVSNK NILFILFQGE TWGYIGSSRV VWDMEQGQFP YKVKDDVKDQ
     IAQINLTHID YFIELEQVGQ PEDINKLYIH TDPISNANPE LKNETDNLLN ILDEASNLVN
     ETKFVRVRKD VPLPPSSIQS FLKHVNISGV VITDHEGEFK NPYYESFLDN YRNVKYEADN
     ETSDADLYHK HINNVASVLA TAIYKLATNT HKKITADPEL TNELLFCYMK NMTCNLVQEY
     GGEMAKHLEP KPAKLYVSVE SGERYRSYVT MYLMAGLLGD EVERNQSDCK IESIYNMNHF
     YYFSHLHNGT CVQTTVRMTE AMSPAFLIDD YDWKSGEYST WTESGWKLTK VMIFLRPSVL
     EEVAVVCGGV VSLVLSVIVV HFMNSRADLL FGLSTPPAAC
//